川芎嗪注射液联合常规疗法对大面积脑栓塞患者支架植入术后血小板血流变学及疗效的影响

发布时间：2019-04-27 10:09

【摘要】：目的:探讨川芎嗪注射液联合常规疗法对大面积脑栓塞患者术后血小板及血流变学的影响。方法:2014年1月~2015年1月,100例大面积脑栓塞患者随机分为对照组和观察组各50例。对照组患者术后采用常规治疗,观察组患者在对照组基础上加用川芎嗪注射液。两组疗程均为2周。比较两组患者治疗前、治疗后1周、治疗后2周的神经功能损失(NIHSS评分)、血小板聚集率及血液流变学(全血黏度、血浆黏度、红细胞变形指数、红细胞聚集指数、纤维蛋白原)指标变化,评价两组疗效与药品不良反应。结果:治疗后,观察组与对照组的有效率分别为92.00%与80.00%,差异无统计学意义(P0.05)。治疗后1周、2周,两组NIHSS评分、血小板聚集率、血液流变学各项指标均较治疗前显著改善(P0.05);且观察组改善较对照组更为明显(P0.05)。观察组药品不良反应发生率明显低于对照组(P0.05)。结论:在常规治疗基础上加用川芎嗪注射液,可抗血小板聚集,改善血液流变学指标,在治疗大面积脑栓塞的疗效确切。
[Abstract]:Objective: to investigate the effect of ligustrazine injection combined with routine therapy on platelet and hemorheology in patients with large area cerebral embolism. Methods: from January 2014 to January 2015, 100 patients with massive cerebral embolism were randomly divided into two groups: control group (n = 50) and observation group (n = 50). The patients in the control group were treated with conventional therapy, and the patients in the observation group were treated with ligustrazine injection on the basis of the control group. The course of treatment in both groups was 2 weeks. The neurological function loss (NIHSS score), platelet aggregation rate and hemorheology (whole blood viscosity, plasma viscosity, erythrocyte deformability index, erythrocyte aggregation index) were compared between the two groups before treatment, 1 week after treatment and 2 weeks after treatment. The changes of fibrinogen (Fibrinogen) index were used to evaluate the efficacy and adverse drug reactions in the two groups. Results: after treatment, the effective rates of observation group and control group were 92.00% and 80.00%, respectively, there was no significant difference (P0.05). One week and two weeks after treatment, the NIHSS score, platelet aggregation rate and hemorheology of the two groups were significantly improved (P0.05), and the improvement of the observation group was more obvious than that of the control group (P0.05). The incidence of adverse drug reactions in the observation group was significantly lower than that in the control group (P0.05). Conclusion: on the basis of routine treatment, ligustrazine injection can inhibit platelet aggregation, improve hemorheological indexes, and is effective in the treatment of large area cerebral embolism.
【作者单位】：宁波市第七医院神经外科;宁波市第七医院急诊内科;宁波市第七医院急诊外科;
【分类号】：R651.12

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