氟比洛芬酯在骨科手术围术期疼痛管理中的临床研究

发布时间：2019-05-07 21:01

【摘要】：目的观察氟比洛芬酯预防性镇痛在骨科手术围术期疼痛管理中的效果。方法随机选取我院择期进行全身麻醉下骨科手术患者100例,按照是否用预防性镇痛分为对照组(不采用预防性镇痛)和试验组(用预防性镇痛),每组50例。试验组是在切皮前15 min给予氟比洛芬酯注射液50 mg+0.9%NaCl 100 mL,静脉滴注;对照组给予0.9%NaCl 100 mL,静脉滴注。用视觉模拟评分(VAS)法评估患者术后6,24,48,72 h静息状态及活动状态下疼痛评分。记录2组补救镇痛、药物不良反应发生情况及患者满意度情况。结果试验组术后6,24,48,72 h静息状态VAS分别为(3.60±1.20),(3.10±1.30),(2.40±0.90),(1.60±0.80)分,对照组分别为(4.40±2.20),(3.80±1.70),(2.90±1.40),(1.90±1.00)分,差异均有统计学意义(均P0.05)。试验组术后6,24,48,72 h活动状态VAS分别为(4.40±1.30),(3.70±1.30),(2.90±0.90),(2.00±0.70)分,对照组分别为(5.10±1.60),(4.90±1.40),(3.50±1.00),(2.60±0.60)分,差异均有统计学意义(均P0.05)。试验组和对照组的药物不良反应均为恶心和呕吐,药物不良反应发生率分别为6.00%(3例/50例)和48.00%(24例/50例),差异有统计学意义(P0.01)。结论氟比洛芬酯预防性镇痛可显著缓解患者术后疼痛程度,提高患者满意度,且药物不良反应发生率低。
[Abstract]:Objective to observe the effect of prophylactic analgesia with flurbiprofen on perioperative pain management in orthopedic surgery. Methods 100 patients undergoing orthopedic surgery under general anesthesia in our hospital were randomly divided into control group (without preventive analgesia) and trial group (with preventive analgesia) according to whether or not preventive analgesia was used, 50 cases in each group were divided into two groups: control group (n = 50) and trial group (n = 50). The experimental group was given flurbiprofen axetil injection 50 mg 0.9%NaCl 100 mL, intravenously at 15 min before skin incision, and the control group was given 0.9%NaCl 100 mL, intravenous drip. Visual analogue score (VAS) was used to evaluate the pain scores at rest and active state at 6, 24, 48, 72 hours after operation. Two groups of relief analgesia, adverse drug reactions and patient satisfaction were recorded. Results the resting VAS scores were (3.60 卤1.20), (3.10 卤1.30), (2.40 卤0.90), (1.60 卤0.80) in the experimental group and (4.40 卤2.20), (3.80 卤1.70) in the control group respectively at 6,24,48,72 hours after operation. (2.90 卤1.40), (1.90 卤1.00), the difference was statistically significant (P0.05). At 6, 24, 48, 72 h after operation, the active state VAS of the experimental group was (4.40 卤1.30), (3.70 卤1.30), (2.90 卤0.90), (2.00 卤0.70), and that of the control group was (5.10 卤1.60), (4.90 卤1.40), and that of the control group was (5.10 卤1.60), (4.90 卤1.40). (3.50 卤1.00), (2.60 卤0.60), the difference was statistically significant (all P0.05). The adverse drug reactions in the test group and the control group were nausea and vomiting. The incidence of adverse drug reactions was 6.00% (3 / 50) and 48.00% (24 / 50), respectively. The difference was statistically significant (P0.01). Conclusion prophylactic analgesia with flurbiprofen axetil can significantly relieve postoperative pain and improve patients' satisfaction, and the incidence of adverse drug reactions is low.
【作者单位】：南京大学医学院附属鼓楼医院药学部;南京大学医学院附属鼓楼医院麻醉科;南京大学医学院附属鼓楼医院骨科;河北省中医院药学部;
【分类号】：R614

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