关节腔注射富血小板血浆对膝骨关节炎患者关节液及血浆中IL-17的影响
发布时间：2019-05-21 16:11
【摘要】：目的探讨关节腔注射富血小板血浆(platelet-rich plasma,PRP)治疗后,膝骨关节炎(osteoarthritis,OA)患者血浆和关节滑液中IL-17水平变化。方法以2015年1月—2016年1月接受关节腔PRP注射治疗(每周1次,连续3周)的30例膝关节OA患者作为研究对象(试验组),以30例自愿者正常膝关节作为对照(对照组)。两组研究对象性别、年龄、体质量指数比较,差异均无统计学意义(P0.05)。试验组治疗前后采用膝关节学会评分系统(KSS)及疼痛视觉模拟评分(VAS)分别评价膝关节功能及疼痛程度。试验组患者注射PRP之前及第3次注射后1、3、6及12个月抽取肘前静脉血以及患侧关节滑液,采用ELISA法测量IL-17含量;对照组抽取肘前静脉血进行相应检测并比较。结果 PRP注射治疗过程中,试验组患者均未出现膝关节红肿、发热等局部感染及其他不适症状。患者均获随访,随访时间12~15个月,平均13.5个月。PRP注射治疗后各时间点VAS评分均较术前显著降低,KSS评分较术前显著增加,比较差异有统计学意义(P0.05);治疗后各时间点间比较,差异均无统计学意义(P0.05)。与对照组比较,试验组PRP治疗前后血浆IL-17含量均显著增高(P0.05)。试验组治疗后各时间点血浆及关节滑液IL-17含量均较治疗前显著降低(P0.05),治疗后各时间点间比较差异均无统计学意义(P0.05)。结论关节腔注射PRP治疗可显著改善膝关节OA患者疼痛症状及关节功能,并在一定程度上降低患者体内IL-17水平,但未恢复至正常水平。
[Abstract]:Objective to investigate the changes of IL-17 levels in plasma and synovial fluid of patients with knee osteoarthritis (osteoarthritis,OA) after intra-articular injection of platelet-rich plasma (platelet-rich plasma,PRP). Methods from January 2015 to January 2016, 30 patients with knee joint OA were treated with PRP injection (once a week for 3 weeks) as the subjects (experimental group) and 30 volunteers as control group (control group). There was no significant difference in sex, age and body mass index between the two groups (P 0.05). The knee joint function and pain degree were evaluated by knee joint learning scoring system (KSS) and pain visual simulation score (VAS) before and after treatment in the experimental group. The blood samples of anterior cubital vein and synovial fluid of affected joint were taken before and 1, 3, 6 and 12 months after injection of PRP in the experimental group, and the content of IL-17 was measured by ELISA method, while the blood of the anterior cubital vein was detected and compared in the control group. Results during PRP injection, there were no local infections such as knee joint redness and swelling, fever and other uncomfortable symptoms in the experimental group. All the patients were followed up for 12 to 15 months (mean 13.5 months). The VAS score was significantly lower and the KSS score was significantly higher at each time point after PRP injection than that before operation (P 0.05). There was no significant difference between the time points after treatment (P 0.05). Compared with the control group, the plasma IL-17 content in the experimental group was significantly higher than that in the control group before and after PRP treatment (P 0.05). The content of IL-17 in plasma and synovial fluid of the experimental group was significantly lower than that before treatment at each time point after treatment (P 0.05), but there was no significant difference between the time points after treatment (P 0.05). Conclusion intra-articular injection of PRP can significantly improve the pain symptoms and joint function of patients with knee joint OA, and decrease the level of IL-17 in patients to a certain extent, but does not return to the normal level.
【作者单位】： 沧州市中心医院骨二科;沧州市人民医院手术室;献县人民医院骨科;
【分类号】：R684.3
[Abstract]:Objective to investigate the changes of IL-17 levels in plasma and synovial fluid of patients with knee osteoarthritis (osteoarthritis,OA) after intra-articular injection of platelet-rich plasma (platelet-rich plasma,PRP). Methods from January 2015 to January 2016, 30 patients with knee joint OA were treated with PRP injection (once a week for 3 weeks) as the subjects (experimental group) and 30 volunteers as control group (control group). There was no significant difference in sex, age and body mass index between the two groups (P 0.05). The knee joint function and pain degree were evaluated by knee joint learning scoring system (KSS) and pain visual simulation score (VAS) before and after treatment in the experimental group. The blood samples of anterior cubital vein and synovial fluid of affected joint were taken before and 1, 3, 6 and 12 months after injection of PRP in the experimental group, and the content of IL-17 was measured by ELISA method, while the blood of the anterior cubital vein was detected and compared in the control group. Results during PRP injection, there were no local infections such as knee joint redness and swelling, fever and other uncomfortable symptoms in the experimental group. All the patients were followed up for 12 to 15 months (mean 13.5 months). The VAS score was significantly lower and the KSS score was significantly higher at each time point after PRP injection than that before operation (P 0.05). There was no significant difference between the time points after treatment (P 0.05). Compared with the control group, the plasma IL-17 content in the experimental group was significantly higher than that in the control group before and after PRP treatment (P 0.05). The content of IL-17 in plasma and synovial fluid of the experimental group was significantly lower than that before treatment at each time point after treatment (P 0.05), but there was no significant difference between the time points after treatment (P 0.05). Conclusion intra-articular injection of PRP can significantly improve the pain symptoms and joint function of patients with knee joint OA, and decrease the level of IL-17 in patients to a certain extent, but does not return to the normal level.
【作者单位】： 沧州市中心医院骨二科;沧州市人民医院手术室;献县人民医院骨科;
【分类号】：R684.3
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