星状神经节阻滞结合三叉神经节脉冲射频治疗面部PHN的效果研究
发布时间：2019-06-03 21:34
【摘要】：目的:分析星状神经节阻滞联合三叉神经节脉冲射频对颜面带状疱疹后遗神经痛(postherpetic neuralgia PHN)的治疗效果,并调查血清IL-2和IL-6在治疗前后的水平变化。方法:选取颜面部PHN病患者60例,按治疗方案分为星状神经节阻滞治疗组(A组),接受三叉神经节脉冲射频治疗(B组),联合两种治疗组(C组),每组20例。分别记录治疗前与治疗后六个月的的视觉模拟评分(visual analogue scale VAS)和生存质量评分(quality of life QOL),疼痛发作时头面部疼的程度,使用镇痛药的剂量,发生及固定时间内出现的次数以及出现时长、有无并发症。采用放射免疫测定法治疗前后患者血清中IL-2和IL-6的水平。结果:治疗前、后6个月VAS评分A组(7.56土0.92 vs 3.31 ±0.40)、B组(7.51±0.80vs 2.81±0.45)和C组(7.63士0.68vs 2.06±0.55),均显著下降并具有统计学差异(P0.001)。治疗前和治疗后6个月的QOL评分进行比较结果A组(34.64±2.83 vs 72.62±2.07)、B 组(33.51±2.47 vs 72.84±2.40)和 C 组(32.12±3.00 vs 79.82±3.79),均显著上升并具有统计学差异(P0.001)。术后6个月疼痛缓解程度百分比C组(70%)明显高于A组(25%)及B组(30%)(P0.05),疼痛发作时持续时间 A 组(10.54±0.31 vs 4.38±0.33)、B 组(10.16±0.49 vs 3.74±0.53)、C 组(10.41 ±0.43 vs 3.41±0.67)较术前均明显减少(P0.05),且具有统计学意义。术后各组血清白介素2水平较术前(A组:2.49±0.81 vs 2.56±0.72;B组:2.52±0.79vs 2.55士0.82;C组:2.54±0.78vs 2.61±0.78ng/ml)均有所上升,但上升幅度不明显(P0.05),白介素6水平相较术前(A组:244.65±48.15vs 243.51±48.12;B组:243.62±47.95 vs 242.61±47.92;C组:242.38±46.95 vs 241.01±46.85 pg/ml)均有所下降,但下降幅度不明显(P0.05)。结论:三叉神经节脉冲射频以及星状神经节相结合的疗法相对于单独行星状神经节阻滞以及三叉神经节脉冲射频这两种方法对于治疗面部PHN的效果有着明显的提升。且上述治疗方法并不能明显改善面部PHN患者血清白介素2以及白介素6的水平。
[Abstract]:Objective: To analyze the therapeutic effect of stellate ganglion block combined with trigeminal ganglion pulse radio frequency on postherpetic neuralgia (PHN), and to investigate the level changes of serum IL-2 and IL-6 before and after treatment. Methods:60 patients with PHN were randomly divided into the group of stellate ganglion block (group A), and received the pulse-frequency therapy of the trigeminal ganglion (group B), and the combination of the two treatment groups (group C) was 20 cases in each group. The visual analogue scale (VAS) and the quality of life QOL (quality of life QOL) before and after the treatment were recorded separately, the degree of the head's face pain during the pain attack, the number of times in which the analgesic was used, the number of times of occurrence and fixation time, and the duration of the occurrence, and the presence or absence of complications. The levels of IL-2 and IL-6 in serum of patients before and after treatment were measured by radioimmunoassay. Results: The VAS scores in group A (7.56, 0.92 vs. 3.31, 0.40), group B (7.51, 0.80 vs 2.81, 0.45) and C (7.63 + 0.68 vs 2.06-0.55) were significantly decreased before and after treatment (P 0.001). The QOL scores before and after treatment were compared in group A (34.64, 2.83 vs 72.62, 2.07), group B (33.51, 2.47 vs 72.84, 2.40) and group C (32.12, 3.00 vs. 79.82, 3.79), both significantly and statistically different (P0.001). The percentage of pain relief in group C (70%) was significantly higher than that in group A (25%) and group B (30%) (P0.05). The duration of pain in group A (10.54, 0.31 vs. 4.38, 0.33), group B (10.16, 0.49 vs. 3.74, 0.53) was significantly higher in group C than in group A (25%) and group B (30%) (P0.05). The group C (10.41-0.43 vs. 3.41-0.67) was significantly reduced before operation (P0.05), and was of statistical significance. The level of IL-2 in the group was 2.49 (0.81 vs 2.56, 0.72; group B: 2.52, 0.79 vs 2.55 + 0.82; Group C: 2.54, 0.78 vs 2.61, 0.78 ng/ ml), but the rise was not significant (P0.05), and the level of interleukin6 was not significant (group A: 244.65, 48.15 vs. 243.51, 48.12; Group B: 243.62 (47.95 vs 242.61, 47.92; Group C: 242.38, 46.95 vs 241.01, 46.85 pg/ ml) decreased, but the decrease was not significant (P0.05). Conclusion: The combination of the trigeminal ganglion pulse radio frequency and the stellate ganglion has a significant improvement in the treatment of the face PHN with respect to the individual planetary ganglion block and the trigeminal ganglion pulse radio frequency. And the treatment method can not obviously improve the level of the serum interleukin 2 and the interleukin 6 in the face PHN patients.
【学位授予单位】：延边大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R614
，
本文编号：2492234
[Abstract]:Objective: To analyze the therapeutic effect of stellate ganglion block combined with trigeminal ganglion pulse radio frequency on postherpetic neuralgia (PHN), and to investigate the level changes of serum IL-2 and IL-6 before and after treatment. Methods:60 patients with PHN were randomly divided into the group of stellate ganglion block (group A), and received the pulse-frequency therapy of the trigeminal ganglion (group B), and the combination of the two treatment groups (group C) was 20 cases in each group. The visual analogue scale (VAS) and the quality of life QOL (quality of life QOL) before and after the treatment were recorded separately, the degree of the head's face pain during the pain attack, the number of times in which the analgesic was used, the number of times of occurrence and fixation time, and the duration of the occurrence, and the presence or absence of complications. The levels of IL-2 and IL-6 in serum of patients before and after treatment were measured by radioimmunoassay. Results: The VAS scores in group A (7.56, 0.92 vs. 3.31, 0.40), group B (7.51, 0.80 vs 2.81, 0.45) and C (7.63 + 0.68 vs 2.06-0.55) were significantly decreased before and after treatment (P 0.001). The QOL scores before and after treatment were compared in group A (34.64, 2.83 vs 72.62, 2.07), group B (33.51, 2.47 vs 72.84, 2.40) and group C (32.12, 3.00 vs. 79.82, 3.79), both significantly and statistically different (P0.001). The percentage of pain relief in group C (70%) was significantly higher than that in group A (25%) and group B (30%) (P0.05). The duration of pain in group A (10.54, 0.31 vs. 4.38, 0.33), group B (10.16, 0.49 vs. 3.74, 0.53) was significantly higher in group C than in group A (25%) and group B (30%) (P0.05). The group C (10.41-0.43 vs. 3.41-0.67) was significantly reduced before operation (P0.05), and was of statistical significance. The level of IL-2 in the group was 2.49 (0.81 vs 2.56, 0.72; group B: 2.52, 0.79 vs 2.55 + 0.82; Group C: 2.54, 0.78 vs 2.61, 0.78 ng/ ml), but the rise was not significant (P0.05), and the level of interleukin6 was not significant (group A: 244.65, 48.15 vs. 243.51, 48.12; Group B: 243.62 (47.95 vs 242.61, 47.92; Group C: 242.38, 46.95 vs 241.01, 46.85 pg/ ml) decreased, but the decrease was not significant (P0.05). Conclusion: The combination of the trigeminal ganglion pulse radio frequency and the stellate ganglion has a significant improvement in the treatment of the face PHN with respect to the individual planetary ganglion block and the trigeminal ganglion pulse radio frequency. And the treatment method can not obviously improve the level of the serum interleukin 2 and the interleukin 6 in the face PHN patients.
【学位授予单位】：延边大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R614
，
本文编号：2492234
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