初次全膝关节置换术后应用低分子肝素对围手术期失血的影响
发布时间：2019-06-24 10:01
【摘要】：目的:观察初次人工全膝关节置换术后应用低分子肝素抗凝对失血量的影响。方法:自2013年09月~2014年10月,山东中医药大学附属医院骨关节科接受Link Gemini MKⅡ人工膝关节假体人工全膝关节置换的72例初次进行膝关节置换的患者,其中男20例,女52例;年龄50到78岁,平均64.31士7.34岁,随机分成两组(治疗组、对照组)。术前查血常规、血生化、凝血功能等,记录血红蛋白及红细胞压积,术中记录出血量、输血量。术后刀口内放置引流管两根,接一个自体血回输器。根据患者术后6小时内引流量进行自体血回输,6小时后治疗组患者应用低分子肝素(万脉舒)Q12H抗凝,对照组患者术后应用低分子肝素(万脉舒)QD抗凝,其他术后治疗及处理均相同,48小时后复查血常规记录血红蛋白及红细胞压积,根据记录数据计算出总失血量、显性失血量、隐性失血量。结果:治疗组36例和对照组36例患者围手术期失血量情况进行统计分析,得出治疗组患者与对照组患者围手术期总失血量分别为:844.58士211.27(ml)和719.36士279.26(ml),P=0.0350.05。即:两组间差异有统计学意义。两组患者显性失血量分别是577.36士177.65(ml)和482.78士187.6(ml),P=0.0310.05,两组间差异有统计学意义。对隐性失血量进行分析得出结果,分别为267.22(ml)士145.36和236.58士145.63(ml),通过比较分析两组P=0.375㧐0.05,即:两组间差异无统计学意义。结论:应用低分子肝素钙(万脉舒)增加用量的同时也增加了术后的失血量。
[Abstract]:Objective: to observe the effect of low molecular weight heparin anticoagulant on blood loss after primary total knee arthroplasty. Methods: from September 2013 to October 2014, 72 patients, including 20 males and 52 females, aged from 50 to 78 years (mean 64.31 卤7.34 years old), underwent total knee arthroplasty with Link Gemini MK II artificial knee arthroplasty in the affiliated Hospital of Shandong University of traditional Chinese Medicine. They were randomly divided into two groups (treatment group, control group). Blood routine, blood biochemistry, coagulation function, hemoglobin and hematocrit were recorded before operation, and blood loss and transfusion were recorded during operation. After operation, two drainage tubes were placed in the knife edge, followed by an autologous blood transfusion device. The patients in the treatment group were treated with low molecular weight heparin (Wanmashu) Q12H anticoagulant within 6 hours after operation, and the patients in the control group were treated with low molecular weight heparin (Wameshu) Q12H anticoagulant within 6 hours after operation. The other treatment and treatment were the same. Hemoglobin and hematocrit were recorded by blood routine examination 48 hours later, and the total blood loss, dominant blood loss and hidden blood loss were calculated according to the recorded data. Results: the perioperative blood loss of 36 patients in the treatment group and 36 patients in the control group were statistically analyzed. The results showed that the total blood loss in the treatment group and the control group were 844.58 卤211.27 (ml) and 719.36 卤279.26 (ml), P 鈮，
本文编号：2504976
[Abstract]:Objective: to observe the effect of low molecular weight heparin anticoagulant on blood loss after primary total knee arthroplasty. Methods: from September 2013 to October 2014, 72 patients, including 20 males and 52 females, aged from 50 to 78 years (mean 64.31 卤7.34 years old), underwent total knee arthroplasty with Link Gemini MK II artificial knee arthroplasty in the affiliated Hospital of Shandong University of traditional Chinese Medicine. They were randomly divided into two groups (treatment group, control group). Blood routine, blood biochemistry, coagulation function, hemoglobin and hematocrit were recorded before operation, and blood loss and transfusion were recorded during operation. After operation, two drainage tubes were placed in the knife edge, followed by an autologous blood transfusion device. The patients in the treatment group were treated with low molecular weight heparin (Wanmashu) Q12H anticoagulant within 6 hours after operation, and the patients in the control group were treated with low molecular weight heparin (Wameshu) Q12H anticoagulant within 6 hours after operation. The other treatment and treatment were the same. Hemoglobin and hematocrit were recorded by blood routine examination 48 hours later, and the total blood loss, dominant blood loss and hidden blood loss were calculated according to the recorded data. Results: the perioperative blood loss of 36 patients in the treatment group and 36 patients in the control group were statistically analyzed. The results showed that the total blood loss in the treatment group and the control group were 844.58 卤211.27 (ml) and 719.36 卤279.26 (ml), P 鈮，
本文编号：2504976
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