降钙素原和C-反应蛋白在老年颅脑手术后颅内感染中的诊断及预后价值分析

发布时间：2019-07-25 17:23

【摘要】：目的分析降钙素原、C-反应蛋白在老年颅脑手术后患者颅内感染中的诊断及预后价值。方法选择2014年5月-2016年6月医院收治的神经外科老年开颅手术患者84例,按患者是否出现颅内感染将其分为感染组和非感染组,检测比较两组患者降钙素原(PCT)、C-反应蛋白(CRP)、白细胞水平(WBC),并对该指标的灵敏度及特异性进行比较评价。结果感染组患者的PCT、CRP、WBC水平在发生颅内感染后显著升高,明显高于非感染组(P0.05);感染组患者经抗感染治疗后PCT及CRP水平逐渐恢复正常,其中PCT水平在治疗后第2天与感染当天出现显著性差异(P0.05);而CRP水平在治疗后第3天与感染当天出现显著性差异(P0.05);PCT诊断术后颅内感染灵敏度91.67%、特异度为88.89%;CRP诊断术后颅内感染灵敏度为89.13%、特异度为80.56%;WBC灵敏度为77.78%、特异度为72.22%;PCT检测的灵敏度、特异度、曲线下面积、95%CI为三个指标中最高,CRP的灵敏度和特异性则较WBC高。结论监测PCT及CRP的水平对老年颅脑手术后颅内感染患者的诊断具有良好的灵敏度及特异性,其PCT及CRP值的变化可有效帮助判断患者的预后。
[Abstract]:Objective to analyze the diagnostic and prognostic value of calmodulin and C-reactive protein in elderly patients with intracranial infection after craniocerebral surgery. Methods from May 2014 to June 2016, 84 elderly patients undergoing neurosurgery craniotomy were divided into infection group and non-infection group according to whether there was intracranial infection or not. Calcitonin C-reactive protein (CRP), leukocyte level (WBC), was detected and compared between the two groups, and the sensitivity and specificity of the index were compared and evaluated. Results the level of PCT,CRP,WBC in the infection group increased significantly after intracranial infection, which was significantly higher than that in the non-infection group (P 0.05). The levels of PCT and CRP in the infection group gradually returned to normal after anti-infection treatment, and there was significant difference in PCT level between the second day after treatment and the day of infection (P 0.05), while the level of CRP in the third day after treatment was significantly different from that on the day of infection (P 0.05). The sensitivity, specificity, specificity and specificity of PCT in the diagnosis of intracranial infection were 91.67%, 88.89%, 80.56%, 77.78%, 72.22% and 72.22%, respectively. The sensitivity and specificity of CRP were the highest among the three indexes, and the sensitivity and specificity of CRP were higher than those of PCT. the sensitivity and specificity of CRP were the highest among the three indexes, and the sensitivity and specificity of CRP were higher than those of PCT. the sensitivity, specificity and specificity of CRP were the highest among the three indexes, and the sensitivity and specificity of CRP were higher than those of PCT. Conclusion Monitoring the level of PCT and CRP has good sensitivity and specificity in the diagnosis of intracranial infection after craniocerebral surgery. The changes of PCT and CRP can effectively help to judge the prognosis of elderly patients with intracranial infection after craniocerebral surgery.
【作者单位】：郑州大学附属肿瘤医院神经外科;
【基金】：河南省科技攻关计划基金资助项目(162102310337)
【分类号】：R651.1

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