两性霉素B联合内镜手术对真菌性鼻-鼻窦炎患者炎症反应及免疫功能的影响

发布时间：2017-12-28 23:02

本文关键词：两性霉素B联合内镜手术对真菌性鼻-鼻窦炎患者炎症反应及免疫功能的影响　出处：《中外医疗》2017年16期 　论文类型：期刊论文

【摘要】：目的探讨两性霉素B联合内镜手术对真菌性鼻-鼻窦炎患者炎症反应及免疫功能的影响。方法便利选择了该院2010年3月—2016年3月收治的真菌性鼻-鼻窦炎患者100例为观察组,再选择同期于该院身体检查健康者100例为对照组;观察组选择两性霉素B联合内镜手术治疗,对照组不给予治疗;比较两组患者的血清炎症指标及免疫功能情况。结果观察组患者术后各项炎症指标均低于术前,差异有统计学意义(P0.05);观察组患者IL-4(153.1±41.9)pg/m L、IL-12(3.6±0.4)ng/m L、超敏C反应蛋白(3.8±2.4)mg/L均优于对照组IL-4(104.8±19.3)pg/m L、IL-12(3.2±0.3)ng/m L、超敏C反应蛋白(2.1±0.4)mg/L,差异有统计学意义(P0.05);两组IL-6(139.5±30.7)mg/L、IL-17(1.8±0.4)pg/m L、脂蛋白(253.2±125.8)mg/L与对照组IL-6(132.8±21.3)mg/L、IL-17(1.5±0.3)pg/m L、脂蛋白(213.5±105.3)mg/L差异无统计学意义(P0.05);观察组患者经治疗后的淋巴细胞总数、CD3+、CD4+、CD8+、Ig G优于术前,但均低于对照组,差异有统计学意义(P0.05)。结论选择两性霉素B联合内镜手术治疗真菌性鼻-鼻窦炎患者,可充分改善患有此症患者的炎性反应与免疫功能。
[Abstract]:Objective to investigate the effects of amphotericin B combined with endoscopic surgery on the inflammatory response and immune function in patients with fungal rhinosinusitis. Convenient method choice of the hospital in March 2010 March 2016 from fungal rhinosinusitis in patients with 100 cases of the observation group, and then select the same period in the hospital health examination in 100 cases as the control group; the observation group selection of amphotericin B combined with endoscopic surgery, the control group received no treatment; compared two groups of patients with serum inflammatory markers and immune function. Results the patients in the observation group after the inflammation index were lower than those before operation, the difference was statistically significant (P0.05); the patients in the observation group IL-4 (153.1 + 41.9) pg/m L, IL-12 (3.6 + 0.4) ng/m L, high sensitive C reactive protein (3.8 + 2.4) mg/L were better than the control group IL-4 (104.8 + 19.3) pg/m L, IL-12 (3.2 + 0.3) ng/m L, high sensitive C reactive protein (2.1 + 0.4) mg/L, the difference was statistically significant (P0.05 two); group IL-6 (139.5 + 30.7) mg/L, IL-17 (1.8 + 0.4) pg/m L, lipoprotein (253.2 + 125.8) and control group (IL-6 mg/L 132.8 + 21.3) mg/L, IL-17 (1.5 + 0.3) pg/m L, lipoprotein (213.5 + 105.3) there was no significant difference of mg/L (P0.05); the total number of patients in the observation group, lymphocytes after treatment CD3+, CD4+, CD8+, Ig, G better than preoperative, but were lower than the control group, the difference was statistically significant (P0.05). Conclusion the combination of amphotericin B and endoscopy in the treatment of fungal rhinosinusitis can improve the inflammatory response and immune function of the patients with this disease.
【作者单位】：福建省泉州市泉港区医院耳鼻喉科;
【分类号】：R765.9
【正文快照】： 鼻窦炎是真菌感染引起,还会侵犯鼻腔,严重影响患者生活质量。在治疗中,药物治疗是首选治疗方法,临床经验显示药物治疗方法虽然有一定效果,但是真菌性鼻窦炎易复发,而且复发率有上升趋势[1],不少研究认为应联合手术治疗,内镜手术治疗因为自身优点得到广泛使用[2]。为分析两性霉

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