氨磷汀配合奈达铂同步放化疗局部晚期鼻咽癌的临床分析

发布时间：2018-02-01 11:54

本文关键词： 氨磷汀奈达铂晚期鼻咽癌　出处：《世界复合医学》2016年02期 　论文类型：期刊论文

【摘要】：目的研究观察氨磷汀配合奈达铂同步放化疗局部晚期鼻咽癌的临床效果。方法从该院2013年6月—2015年5月间收治的局部晚期鼻咽癌患者中选取82例进行分组研究,对照组给予奈达铂+调强适型放疗治疗局部晚期鼻咽癌,观察组在对照组基础上加用氨磷汀配合治疗,观察两组间近期疗效、毒副作用的发生及其他不良反应等比较。结果对照组近期临床疗效中有效率为97.56%、观察组为95.12%,两组差异无统计学意义(P0.05);随访1年内两组患者近期疗效,比较两组局部控制率均在87.8%~95.12%之间,远处转移均在2.44%~7.32%之间,两组差异无统计学意义(P0.05);毒副作用比较中骨髓抑制、黏膜炎、口干燥症3项对照组比观察组的发生程度更高,而肝脏、肾脏毒性则两组程度相当,故骨髓抑制、黏膜炎、口干燥症中差异有统计学意义(P0.05),而肝脏和肾脏毒性中差异无统计学意义(P0.05);在3级或3级以上黏膜炎发生率中对照组明显比观察组多,平均持续时间长,两组组间差异有统计学意义(P0.05);观察组中患者的白细胞、血红蛋白和血小板降低率中均比对照组少,两组组间差异具有统计学意义(P0.05)。结论氨磷汀配合奈达铂同步放化疗局部晚期鼻咽癌具有减低相关毒副作用对人体正常细胞起到防护的作用,具有临床实用推广的价值。
[Abstract]:Objective to study the clinical effect of amphotin combined with nedatin in local advanced nasopharyngeal carcinoma (NPC). Methods 82 patients with locally advanced nasopharyngeal carcinoma were selected from June 2013 to May 2015 in our hospital. Cases were divided into groups. The patients in the control group were treated with Nedaplatin intensity modulated and appropriate radiotherapy for locally advanced nasopharyngeal carcinoma, and the observation group was treated with amphotin plus amphotin on the basis of the control group, and the short-term curative effect was observed between the two groups. Results the effective rate of clinical efficacy in the control group was 97.56, and that in the observation group was 95.125.There was no significant difference between the two groups (P 0.05). The local control rate of the two groups was between 87.8% and 95.12%, and the distant metastasis was between 2.44% and 7.32%. There was no significant difference between the two groups (P 0.05). Side effects of bone marrow suppression, mucositis, dryness of the three control group than the observation group, but the liver, kidney toxicity of the two groups of the same degree, so bone marrow suppression, mucositis. There was a significant difference in xerostomia (P 0.05), but there was no significant difference in liver and kidney toxicity (P 0.05). The incidence of grade 3 or more mucositis in the control group was significantly higher than that in the observation group, and the mean duration was longer. The difference between the two groups was statistically significant (P 0.05). The leukocyte, hemoglobin and thrombocytopenia rates in the observation group were lower than those in the control group. The difference between the two groups was statistically significant (P 0.05). Conclusion the combination of aminophosphastine and nedaplatin in local advanced nasopharyngeal carcinoma has a protective effect on human normal cells by reducing the related toxicity and side effects. It has the value of clinical practical popularization.
【作者单位】：广西科技大学第二附属医院放疗科;
【基金】：广西卫生厅自筹经费科研课题项目编号(合同号Z2013146)
【分类号】：R739.63
【正文快照】： 鼻咽癌是位于鼻咽部位黏膜上皮层的恶性肿瘤疾病,是我国南方沿海地区最常见的恶性肿瘤之一,现阶段对鼻咽癌的研究发现,鼻咽癌的病因主要是来自基因遗传、外部环境和EB病毒感染导致的,据世界卫生组织的不完全统计,80%的鼻咽癌发生在中国,严重威胁到了人们的生命健康,也是中国卫

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