益生菌辅助治疗儿童支气管哮喘伴变应性鼻炎的疗效及机制研究

发布时间：2018-02-20 00:27

本文关键词： 支气管哮喘变应性鼻炎益生菌 Th/Th　出处：《儿科药学杂志》2016年12期 　论文类型：期刊论文

【摘要】：目的:探讨益生菌辅助治疗儿童支气管哮喘伴变应性鼻炎(AR)的疗效及机制。方法:选取100例哮喘伴AR患儿,随机分为观察组和对照组各50例,对照组给予常规治疗,观察组在对照组治疗基础上联合双歧杆菌乳杆菌三联活菌散治疗,连续治疗6个月。比较两组患儿哮喘控制测试(C-ACT)量表评分、第1秒用力肺活量(FEV1)、呼气峰值流速(PEF)、鼻部症状评分及血清干扰素-γ(IFN-γ)和白介素-4(IL-4)水平。结果:治疗后,观察组C-ACT评分、FEV1、PEF、鼻部症状评分、IFN-γ及IL-4分别为(24.6±2.3)分、123.7%±10.6%、(125.2±8.3)L/min、(0.5±0.2)分、(43.6±4.8)g/L及(32.4±3.9)ng/L,对照组分别为(20.1±2.0)分、108.4%±14.3%、(110.8±7.4)L/min、(0.9±0.3)分、(35.2±3.9)g/L及(44.8±4.7)ng/L,与对照组比较,观察组C-ACT评分、FEV1、PEF、IFN-γ提高(P0.05),同时鼻部症状评分及IL-4降低(P0.05)。结论:益生菌辅助治疗哮喘伴AR可有效缓解临床症状,纠正Th1/Th2免疫失衡是其可能的作用机制。
[Abstract]:Objective: to investigate the therapeutic effect and mechanism of probiotic adjuvant therapy for children with allergic rhinitis. Methods: 100 children with asthma accompanied with AR were randomly divided into two groups: the observation group (n = 50) and the control group (n = 50). The observation group was treated with Bifidobacterium Lactobacillus triple active powder for 6 months on the basis of the control group. The scores of C-ACTS were compared between the two groups in asthma control test. 1 seconds forced vital capacity (RV1), peak expiratory flow rate (PEFV), nasal symptom score and serum levels of IFN- 纬 and IL-4. Results: after treatment, The C-ACT scores of FEV1 / PEF, nasal symptom scores, IFN- 纬 and IL-4 were 123.7% 卤10.6% 卤125.2 卤8.3L / min and 0.5 卤0.2), respectively, 43.6 卤4.8g / L and 32.4 卤3.9ng / L / L respectively, and 108.4% 卤14.3ng / L / L respectively, 108.4% 卤14.3L / min 0.9 卤0.3% and 35.2 卤3.9g / L and 44.8 卤4.7ng / L / L, respectively, compared with those in the control group, which were 108.4% 卤14.3L 卤7.4L / min 0.9 卤0.3% and 35.2 卤3.9g / L and 44.8 卤4.7ng / L / L respectively, compared with those in the control group. C-ACT score of observation group and FEV1PEFFIFN- 纬 increased P0.05, while nasal symptom score and IL-4 decreased P0.05.Conclusion: probiotic adjuvant treatment of asthma with AR can effectively alleviate clinical symptoms, correct Th1/Th2 immune imbalance is its possible mechanism.
【作者单位】：江苏省镇江市中西医结合医院;江苏省镇江市第一人民医院;
【分类号】：R725.6;R765.21

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