氧诱导视网膜病变小鼠模型的研究进展

发布时间：2018-02-27 10:09

本文关键词： 早产儿视网膜病新生血管化氧诱导视网膜病变动物模型　出处：《第二军医大学学报》2017年11期 　论文类型：期刊论文

【摘要】：视网膜新生血管性疾病是一类严重的致盲性疾病,构建与之相关的动物模型是进行该疾病机制研究的重要基础,有利于在临床中更好地预防、诊断和治疗。氧诱导视网膜病变小鼠模型是目前研究视网膜新生血管性疾病最常用的动物模型,此模型构建过程与人类早产儿视网膜新生血管病变的发生、发展极为相似,具有制作方法简单、重复性好等优点。本文重点阐述氧诱导视网膜病变小鼠模型的构建方法及原理,模型相关细胞因子的作用,模型构建的影响因素如动物品种、氧气的百分含量、高氧对母鼠的影响、产后体质量增加量、光照暴露等,并简要介绍模型中常用的量化评估方法,为研究人员准确、有效地构建和评估氧诱导视网膜病变小鼠模型提供帮助。
[Abstract]:Retinal neovascularization disease is a kind of serious blindness disease. The establishment of animal model is an important basis to study the mechanism of retinal neovascularization, which is beneficial to better prevention in clinic. The mouse model of oxygen-induced retinopathy is the most commonly used animal model to study retinal neovascularization disease. The process of this model is very similar to the occurrence of retinal neovasculopathy in human premature infants. This paper focuses on the construction method and principle of oxygen-induced retinopathy mouse model, the role of model related cytokines, the factors influencing model construction, such as animal breeds, and so on. The content of oxygen, the effect of hyperoxia on the female rats, the increase of postpartum body mass, the exposure to light, and so on. The quantitative evaluation methods commonly used in the model are briefly introduced, which are accurate for the researchers. To construct and evaluate the oxygen-induced retinopathy model in mice effectively.
【作者单位】：第二军医大学长海医院眼科;
【基金】：国家自然科学基金(81470652)~~
【分类号】：R-332;R774.1

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