鼻咽癌患者唾液中EB病毒特异性抗体检测

发布时间：2018-03-05 17:34

本文选题：唾液　切入点：鼻咽癌　出处：《福建医科大学》2012年硕士论文　论文类型：学位论文

【摘要】：【目的】通过对鼻咽癌患者唾液中VCA/lgA、EA/lgA抗体含量进行检测，探讨其在鼻咽癌早期诊断及辅助诊断中的价值【方法】试验组为48例鼻咽癌患者，，对照组为62例正常健康体检者。采集受试者唾液和血液标本,运用ELISA法检测所有标本中抗体水平。【结果】鼻咽癌患者唾液和血液中VCA/lgA、EA/lgA抗体含量显著高于健康对照组。ROC曲线下面积:唾液和血液中VCA/lgA分别为0.849和0.902、EA/lgA分别为0.801和0.870，根据ROC曲线分析，cut-off值分别为5.11、4.09、5.31、5.16时，其敏感性和特异性唾液中VCA/lgA为86.5%和84.9%、血液VCA/lgA为91.7%和60.92%、唾液EA/lgA为68.8%和86.5%、血液EA/lgA为81.3%和82.7%。【结论】唾液中VCA/IgA、EA/IgA抗体检测对鼻咽癌患者的筛查、辅助诊断均具有一定的价值。
[Abstract]:[purpose]. In order to evaluate the value of VCA / lgAU / EA / lgA antibody in the early diagnosis and auxiliary diagnosis of nasopharyngeal carcinoma (NPC), we detected the level of VCA / lgAV / lgA antibody in saliva of nasopharyngeal carcinoma patients. [methods]. There were 48 patients with nasopharyngeal carcinoma and 62 healthy controls. The saliva and blood samples were collected and the antibody levels in all samples were detected by ELISA method. [results]. The VCA/lgA in saliva and blood of nasopharyngeal carcinoma patients were 0.801 and 0.870, respectively, and the VCA/lgA in saliva and blood were 0.801 and 0.870, respectively. According to the analysis of ROC curve, the values of VCA / lgA were 5.114.95.31 and 5.16, respectively. Its sensitivity and specificity were 86.5% and 84.9 in saliva, 91.7% and 60.92 in blood VCA/lgA, 68.8% and 86.5 in saliva EA/lgA, 81.3% and 82.7 in blood EA/lgA. [conclusion]. The detection of VCA / IgA / EA / IgA antibody in saliva is valuable for screening and auxiliary diagnosis of nasopharyngeal carcinoma (NPC) patients.
【学位授予单位】：福建医科大学
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R739.63

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