鼻咽部肿瘤体积在中国西北非高发区鼻咽癌患者中的预后价值

发布时间：2018-03-07 17:14

  本文选题：鼻咽癌　切入点：肿瘤体积　出处：《西安交通大学学报(医学版)》2017年01期 　论文类型：期刊论文

【摘要】：目的探索鼻咽部肿瘤体积在中国西北非高发区鼻咽癌患者中的预后价值。方法将2004-2011年接受根治性放疗的393例鼻咽癌患者纳入本研究,所有患者均通过鼻咽部组织活检明确为鼻咽癌,观察总生存率和无远处转移生存率,采用ROC曲线确定肿瘤体积最佳界值,Kaplan-Meier比较患者生存差异,COX比例风险回归模型探索独立预后因素。结果患者5年总生存率和无远处转移生存率分别为74.3%和73.5%。根据肿瘤体积最佳界值将患者分为≤23mL组和23mL组,≤23mL组患者5年总生存率和无远处转移生存率明显高于23mL组,差异有统计学意义(P0.05)。多因素分析显示病理类型为分化亚型、肿瘤体积23mL、N2~3为影响患者总生存率和无远处转移生存率的独立预后因素。结论鼻咽部肿瘤体积是影响中国西北非高发区鼻咽癌患者生存的独立预后因素。
[Abstract]:Objective to explore the prognostic value of nasopharyngeal tumor volume in nasopharyngeal carcinoma (NPC) patients in non-high incidence areas of northwest China. Methods 393 patients with nasopharyngeal carcinoma received radical radiotherapy from 2004 to 2011 were included in this study. All the patients were identified as nasopharyngeal carcinoma by nasopharyngeal biopsy, and the overall survival rate and distant metastasis-free survival rate were observed. ROC curve was used to determine the best cutoff value of tumor volume. Kaplan-Meier compared survival difference of patients with Cox proportional risk regression model to explore independent prognostic factors. Results the 5-year overall survival rate and distant metastasis-free survival rate were 74.3% and 73.5 respectively. The best cutoff of tumor volume was divided into 鈮，

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