血清中期因子联合总胆红素在糖尿病视网膜病变中的诊断价值

发布时间：2018-03-18 13:01

本文选题：血清中期因子　切入点：总胆红素　出处：《中国糖尿病杂志》2017年02期 　论文类型：期刊论文

【摘要】：目的探讨血清中期因子(MK)、总胆红素(TB)在糖尿病视网膜病变(DR)中的诊断价值。方法将148例T2DM患者按照是否出现DR分为糖尿病无DR组(NDR)50例、非增殖性DR组(NPDR)52例和增殖性DR组(PDR)46例,评价MK和TB在DR中的诊断价值。结果各组年龄、性别、BMI、FPG、HbA_1c、TG、TC、LDL-C、HDL-C、SBP、DBP比较,差异无统计学意义(P0.05);各组病程、尿白蛋白/肌酐比(UAlb/Cr)、超氧化物歧化酶(SOD)、丙二醛(MDA)、晚期氧化蛋白产物(AOPP)、MK、TB和直接胆红素(DB)比较,差异有统计学意义(P0.05)。PDR组和NPDR组病程、UAlb/Cr、MDA、AOPP、MK高于NDR组(P0.05),SOD、TB、DB低于NDR组(P0.05)。PDR组病程、UAlb/Cr、MDA、AOPP、MK高于NPDR组(P0.05),SOD、TB、DB低于NPDR组(P0.05)。Logistic回归分析显示,病程、UAlb/Cr、MDA、AOPP、MK为DR的危险因素(OR值为1.36、1.71、1.27、1.65、2.35,P0.05),SOD、TB、DB为DR的保护因素(OR值为0.46、0.31、0.46,P0.05)。TB+MK诊断的敏感性、特异性、阳性预测值、阴性预测值、诊断准确率均高于TB、MK单独诊断效果[曲线下面积(AUC)分别为0.918、0.735、0.762,P0.05]。结论 DR可能与体内MK升高、TB下降有关,MK联合TB对DR的诊断效能优于MK、TB单一指标。
[Abstract]:Objective to investigate the diagnostic value of serum MKG (total bilirubin) in patients with diabetic retinopathy (Dr). Methods 148 patients with T2DM were divided into diabetic non-Dr group (n = 50), non-proliferative Dr group (n = 52) and proliferative Dr group (n = 46). Results the diagnostic value of MK and TB in Dr was evaluated. Results there was no significant difference in age, sex, age and sex of BMIFPGG, HbA1cTGG, LDL-C, HDL-CU, SBP, DBP, the course of disease in each group, and the course of disease in each group was significantly higher than that in the control group (P < 0.05), and no significant difference was found in the diagnosis of MK and TB in Dr. Urinary albumin / creatinine ratio (UAlb / Cr), superoxide dismutase (SOD), malondialdehyde (malondialdehyde) (MDAA), advanced oxidized protein (AOPP) MKT TB, and direct bilirubin (DBB) were compared. There was significant difference between the two groups in the course of disease of UAlb / Cru MDAAOPPnP MK higher than that in NDR group (P 0.05). The course of disease in PDR group was lower than that in NDR group (P 0.05) .The course of disease in PDR group was higher than that in NPDR group (P 0.05). Logistic regression analysis showed that the UAlb / MDAAOPPMK level in PDR group was higher than that in NPDR group, and it was lower than that in NPDR group (P 0.05 .Logistic regression analysis). The OR value of UAlb / MDAAOPPK as Dr was 1.36 / 1.71 / 1.271.271.165 / 2.35 / 2. 05 / TBnDB as the protective factor for Dr. The OR value of the risk factor for Dr was 0.466 / 0.31 / 0.46P0.05. TB / MK sensitivity, specificity, positive predictive value, negative predictive value, and negative predictive value, respectively. The diagnostic accuracy of MK alone was higher than that of TBX MK alone [the area under the curve was 0. 918 卤0. 735 + 0. 762 (P0.05), respectively] conclusion Dr may be related to the increase of MK and the decrease of TB in vivo, and the diagnostic efficacy of MK combined with TB is better than that of MKT.
【作者单位】：福建医科大学附属第二医院眼科;福建医科大学附属第二医院内分泌科;
【分类号】：R587.2;R774.1

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