葡萄膜炎继发黄斑囊样水肿的临床研究

发布时间：2018-03-20 17:14

本文选题：葡萄膜炎　切入点：黄斑囊样水肿　出处：《眼科新进展》2017年02期 　论文类型：期刊论文

【摘要】：目的观察葡萄膜炎继发黄斑囊样水肿(cystoid macular edema,CME)的预后及其影响因素。方法回顾性分析2011年8月至2015年12月于天津医科大学眼科医院确诊为葡萄膜炎继发CME的31例(41眼)患者临床资料。观察治疗前后最佳矫正视力(best corrected visual acuity,BCVA)、黄斑中心凹视网膜厚度(central macular thickness,CMT)、黄斑其他并发症以及眼压变化。结果 27例(36眼)纳入数据分析。治疗后1个月,14眼(38.9%)CME完全缓解,BCVA(0.40±0.31)Log MAR较治疗前(0.66±0.36)Log MAR显著提高(P0.001),CMT(368.7±85.9)μm较治疗前(469.0±99.1)μm显著降低(P0.001)。治疗后3个月,19眼(52.8%)CME完全缓解,BCVA(0.37±0.32)Log MAR及CMT(323.9±60.0)μm与治疗后1个月差异均无统计学意义(均为P0.05),与治疗前差异均有统计学意义(均为P0.001)。治疗后6个月,25眼(69.4%)CME完全缓解,BCVA(0.32±0.28)Log MAR与治疗前、治疗后1个月及3个月差异均有统计学意义(均为P0.05)。CMT(294.2±81.2)μm与治疗前及治疗后1个月差异均有统计学意义(均为P0.001),与治疗后3个月差异无统计学意义(P0.05)。治疗后6个月,11眼(30.6%)仍然存在CME,均伴发黄斑前膜。CMT的降低幅度(185.0±114.2)μm与BCVA的提高幅度(0.29±0.21)Log MAR之间无明显相关性(r=0.322,P=0.052),BCVA的提高幅度(0.29±0.21)Log MAR与CME病程(8.4±9.8)个月之间呈负相关(r=-0.395,P=0.015)。结论目前现有全身和局部治疗可以有效治疗多数葡萄膜炎继发的CME,同时改善视力。视力改善程度与CME病程相关,黄斑前膜是影响黄斑水肿消退的重要因素。
[Abstract]:Objective to observe the prognosis and influencing factors of cystoid macular edemaform edema secondary to uveitis. Methods 31 cases of CME secondary to uveitis were analyzed retrospectively from August 2011 to December 2015 in Tianjin Medical University Ophthalmology Hospital. Observation of best corrected visual acuteness before and after treatment, central macular thickness of macular fovea, other complications of macular and intraocular pressure. Results 27 cases (36 eyes) were included in the data analysis. BCVA0.40 卤0.31 log MAR was significantly increased in 14 eyes after one month compared with that before treatment (P 0.001) MAR (368.7 卤85.9) 渭 m. There was no significant difference between the two groups (P 0.05) after 3 months of treatment (P 0.05), and no significant difference was found between the two groups (P 0.05), and no significant difference was found between before and after treatment (P 0.05), and no significant difference was found between the two groups (P 0.05), and no significant difference was found between the two groups (P 0.05, P 0.05), and no significant difference was found between before and after treatment (P 0.05), and there was no significant difference between the two groups (P 0.05) after 3 months of treatment, and there was no significant difference between the two groups in the complete remission of BCVA (0.37 卤0.32 log MAR and CMT(323.9 卤60.0) 渭 m after 3 months of treatment (P 0.05 卤99.1 渭 m, P 0.05). There were significant differences between the two groups before and after treatment (P 0.001). After 6 months of treatment, there were 25 eyes and 69.4 eyes with complete remission, BCVA0. 32 卤0. 28 log MAR and before treatment. There were significant differences between 1 month and 3 months after treatment (both P0.05U. CMT 294.2 卤81.2) 渭 m and before treatment and 1 month after treatment (P 0.001), and there was no significant difference between treatment and 3 months after treatment (P 0.05N), 6 months after treatment, 11 months after treatment, 11 months after treatment, 11 months after treatment, 11 months after treatment, 11 months after treatment, 11 months after treatment, 11 months after treatment, 11 months after treatment, there was no significant difference between the two groups. There was no significant correlation between the decrease of macular membrane. CMT (185.0 卤114.2) 渭 m and BCVA (0. 29 卤0. 21 log MAR). Conclusion there is a negative correlation between 0. 29 卤0. 21 MAR and 8. 4 卤9. 8 months of CME. Conclusion there is a negative correlation between the increase of 0. 322 卤0. 21 MAR and CME duration of 8. 4 卤9. 8 months. Conclusion there is a negative correlation between 0. 29 卤0. 21 log MAR and 8. 4 卤9. 8 months of the course of disease of CME. Conclusion there is no significant correlation between the increase of 0. 29 卤0. 21 and 0. 29 卤0. 21 MAR. Conclusion there is a negative correlation between 0. 29 卤0. 21 MAR and 8. 4 卤9. 8 months. Partial treatment can be effective in the treatment of most cases of uveitis, while improving visual acuity. The improvement of visual acuity is related to the course of CME. The macular membrane is an important factor affecting the regression of macular edema.
【作者单位】：天津医科大学眼科医院;
【分类号】：R773;R774.5

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