鼻咽癌同期放化疗体质量下降规律及预测因素

发布时间：2018-03-24 23:15

本文选题：鼻咽癌　切入点：同期放化疗　出处：《实用医学杂志》2017年16期

【摘要】：目的研究鼻咽癌同期放化疗期间体质量下降规律及相关预测因素。方法回顾性收集广州医科大学附属肿瘤医院82例鼻咽癌同期放化疗患者,中位年龄45岁。运用配对t检验分析放化疗期间患者体质量下降情况,采用Spearman′s秩相关分析探讨高体质量下降(HWL)与临床因素的相关性。结果配对t检验分析发现,同期放化疗期间患者体质量呈每周连续下降(均P0.05),其中在第4周下降数值最大。82例患者中32例判定为HWL(体质量下降10%)。Spearman′s秩相关分析显示:HWL与年龄40岁、女性、较高T分期和TNM分期、3D-CRT技术、较高鼻咽和颈淋巴放疗剂量、Ⅱ度以上白细胞下降、血红蛋白下降相关(均P0.05)。结论鼻咽癌同期放化疗期间患者体质量持续下降,年龄、性别、T分期、TNM分期、放疗技术、鼻咽和颈部淋巴放疗剂量、白细胞下降程度、血红蛋白下降可能是鼻咽癌放化疗期间体质量下降程度的预测因素。
[Abstract]:Objective to study the decline of body mass in nasopharyngeal carcinoma (NPC) during concurrent radiotherapy and chemotherapy. Methods 82 patients with nasopharyngeal carcinoma (NPC) were collected retrospectively from Cancer Hospital affiliated to Guangzhou Medical University. The median age was 45 years old. T test was used to analyze the decline of body mass during radiotherapy and chemotherapy, and Spearman's rank correlation analysis was used to study the correlation between high body mass drop and clinical factors. During the same period of radiotherapy and chemotherapy, the body mass of the patients decreased weekly (all P 0.05%). In the fourth week, 32 out of 82 patients were identified as HWLL (10%).Spearman's rank correlation analysis of body mass drop showed that the weight of weight decreased to 40 years old, female, female). Higher T stage and TNM staging 3D-CRT technique, higher radiotherapy dose of nasopharyngeal and cervical lymph nodes, lower leucocytopenia and lower hemoglobin (all P 0.05). Conclusion the body mass of patients with nasopharyngeal carcinoma decreases continuously during the same period of radiotherapy and chemotherapy. Sex T staging TNM staging radiotherapy technique radiotherapy dose of nasopharyngeal and cervical lymphatic radiotherapy leukopenia and hemoglobin decrease may be the predictors of the decrease of body mass during radiotherapy and chemotherapy of nasopharyngeal carcinoma.
【作者单位】：广州医科大学附属肿瘤医院放疗科;
【基金】：国家自然科学基金项目(编号:81502342) 广州市科技计划项目(编号:151500085)
【分类号】：R739.63

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