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过敏性结膜炎与泪膜脂质层厚度变化的相关性研究

发布时间:2018-03-29 08:12

  本文选题:过敏性结膜炎 切入点:泪膜稳定性 出处:《郑州大学》2017年硕士论文


【摘要】:背景和目的测量季节性或常年性过敏性结膜炎患者的泪膜脂质层厚度,并将测定结果及其他泪液相关检查结果与正常人群进行对比。探索过敏性结膜炎患者和泪膜脂质层厚度变化的原因及同泪膜稳定性改变的关系,以期指导临床诊疗。材料和方法选取2016年12月至2017年2月于河南省人民医院眼科门诊就诊的患者,通过询问病史和症状体征诊断为季节性或常年性过敏性结膜炎且结膜刮片细胞学检查发现存在嗜酸性粒细胞、嗜酸颗粒和/或肥大细胞患者52例(104眼)为实验观察组,招募无全身疾患?无干眼症和其他眼表疾患51例健康志愿者(102眼)为对照组,分别进行泪膜脂质层厚度测量、泪膜脂质层形态分级评分、泪液分泌实验检查、泪膜破裂时间测定、泪河高度测量和睑板腺功能评估诊断睑板腺功能障碍。采用SPSS 21.0对数据进行统计分析,比较过敏性结膜炎患者同健康受试者不同参数结果之间的差异性。结果过敏性结膜炎患者LLT为56.97±20.43nm,其中泪膜脂质层厚度LLT≤60nm为70只眼(约占总数66.04%),泪膜脂质层厚度LLT≥75nm为7只眼(约占总数6.61%)。健康受试者LLT为87.40±28.17nm,泪膜脂质层厚度LLT≤60nm为18只眼(约占总数17.65%),泪膜脂质层厚度LLT≥75nm为64只眼(约占总数62.75%)。过敏性结膜炎患者和健康志愿者的泪膜脂质层厚度(P0.05)和泪膜脂质层检查阳性结果(LLT≤60nm)眼数占总眼数的比率(P0.05)均存在显著差异性。过敏性结膜炎患者的泪膜破裂时间为2.77±1.32s,健康志愿者的泪膜破裂时间为3.55±1.11s,两个组之间存在显著差异性(P0.05);泪过敏性结膜炎患者的泪膜脂质层形态分级评分为2.91±0.61,健康志愿者的膜脂质层形态分级评分为3.08±0.65,两组之间存在显著差异性(P0.05)。过敏性结膜炎患者出现睑板腺功能障碍眼数/总眼数比率为34/40(85%),健康志愿者出现睑板腺功能障碍的比率为7/32(21.9%),两组之间存在显著差异性(P0.05)。结论过敏性结膜炎患者的泪膜脂质层厚度低于健康受试者,是导致过敏性结膜炎患者泪膜稳定性下降的一个重要原因。过敏性结膜炎引起的睑板腺功能障碍为泪膜脂质层厚度变薄的一个重要原因。
[Abstract]:Background and objective to measure the thickness of tear film lipid layer in patients with seasonal or perennial allergic conjunctivitis. The results of measurement and other tear related examinations were compared with those of normal subjects to explore the causes of changes in the thickness of the lipid layer of the lacrimal film in patients with allergic conjunctivitis and the relationship between the changes in the stability of the lacrimal film and the changes in the thickness of the lipid layer. Materials and methods selected patients from December 2016 to February 2017 in the ophthalmological clinic of Henan Provincial people's Hospital. Eosinophilic granulocytes were found in the patients with seasonal or perennial allergic conjunctivitis and conjunctival scraper cytology, with 52 patients with eosinophil and / or mast cells (104 eyes) as experimental observation group. Recruiting without systemic disease? 102 eyes of 51 healthy volunteers without xerophthalmia and other ocular surface diseases were used as control group. The thickness of lacrimal film lipid layer, the morphological grading of lacrimal film lipid layer, the experimental examination of lacrimal secretion and the time of tear film rupture were measured respectively. Canine height measurement and meibomian gland function evaluation were used to diagnose tarsal gland dysfunction. The data were statistically analyzed by SPSS 21. 0. Results the LLT of patients with allergic conjunctivitis was 56.97 卤20.43 nm, and the thickness of lipid layer of tear film LLT 鈮,

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