食管动力和反流事件在OSAHS发病机制中意义

发布时间：2018-04-03 10:25

  本文选题：睡眠呼吸暂停　切入点：阻塞性　出处：《中华胃食管反流病电子杂志》2014年01期

【摘要】：目的探讨阻塞性睡眠呼吸暂停低通气综合征(obstructive sleep apnea hypopnea syndrome,OSAHS)与胃反流性疾病(gastroesophageal reflux disease)的关系。方法 2013年2月至2014年6月期间就诊于新疆维吾尔自治区人民医院的OSAHS患者30例,采用多导睡眠监测、24 h多通道腔阻抗-p H监测和高分辨率胃肠动力学检查系统进行监测,观察食管上、下括约肌、食管动力学特点及反流事件相关指标,并与10例健康成人对照组比较,比较组间各测量指标差异。结果OSAHS组较对照组食管上括约肌松弛持续时间、食管上括约肌松弛恢复时间、食管下括约肌长度、远端收缩积分平均值均减小,收缩前沿速度增加,差异均具有统计学意义(t=-2.061、-2.044、-2.525、-2.076、2.522,P均0.05)。OSAHS组与对照组中De Meester评分中位数(M[P25;P75])分别为11.3[5.1;37.8]、3.8[2.8;11.1]分。食管近端反流总次数分别为41.5[23.8;65.3]、24.5[16.3;27.8]次,酸反流次数分别为20.0[10.0;32.0]、10.5[7.8;14.3]次。OSAHS组食管近端反流总次数、酸反流次数及De Meester评分均较对照组增加,差异均有统计学意义(z=-2.438、-2.361、-2.140,P均0.05)。结论 OSAHS部分患者存在食管上、下括约肌结构和功能障碍,存在胃食管反流现象,食管近端反流以酸性物质为主。
[Abstract]:Objective to investigate the relationship between obstructive sleep apnea hypopnea syndrome (OSAHS) and gastroesophageal reflux disease (GRS) in patients with obstructive sleep apnea hypopnea syndrome (OSAHS).Methods from February 2013 to June 2014, 30 patients with OSAHS were treated in Xinjiang Uygur Autonomous region people's Hospital. The patients were monitored by multi-channel cavity impedance (-pH) monitoring and high-resolution gastrointestinal dynamic examination system for 24 h with polysomnography.The upper esophageal sphincter, lower sphincter, esophageal dynamics and reflux events were observed and compared with 10 healthy adults.Results the relaxation duration of upper esophageal sphincter, the recovery time of upper esophageal sphincter relaxation, the length of lower esophageal sphincter, the mean value of distal contraction integral in OSAHS group were decreased, and the velocity of contraction front increased.The difference was statistically significant (P < 0.05). The median de Meester score in 0.05).OSAHS group and control group was 11.3 [5.1-37.8] 卤3.8 [2.8 卤11.1], respectively.椋熺�¤繎绔�鍙嶆祦鎬绘�℃暟鍒嗗埆涓�41.5[23.8;65.3],24.5[16.3;27.8]娆，

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