青年近视患者LASIK术后远期干眼随访研究

发布时间：2018-04-27 09:36

本文选题：青年近视 + LASIK　；参考：《眼科新进展》2017年08期

【摘要】：目的随访青年近视患者LASIK术后远期干眼。方法以LASIK手术患者为治疗组(A组),非手术单纯近视患者为对照组(B组),分别于术前及术后1 a、3 a、5 a检查患者裸眼视力、屈光度、泪膜破裂时间、角膜荧光素染色和泪液分泌试验,诊断并填写眼表疾病指数(ocular surface disease index,OSDI)调查问卷。结果A组术后干眼发病率高于术前(35.6%)且随时间降低(术后1 a、3 a、5 a分别为51.7%、44.9%和40.7%),B组各时间点间差异无统计学意义(P0.05);两组比较,术前差异无统计学意义(P0.05),术后其他时间A组均高于B组(均为P0.05)。A组术后轻度干眼占多数但逐年减少(分别为65.6%、52.8%和41.7%),中度和重度干眼构成逐年提高,且重度干眼更为明显(分别为6.6%、11.3%和16.7%;P0.05)。术后5 a,干眼患者裸眼视力和视觉功能OSDI评分均明显低于非干眼患者(均为P0.05),残留屈光度和眼部症状OSDI评分明显高于非干眼患者(均为P0.05)。结论青年近视患者LASIK术后干眼长期存在甚至可能加重,要长期关注青年近视患者LASIK术后干眼进展。
[Abstract]:Objective to follow up the long-term dry eyes of young myopia patients after LASIK. Methods the patients with LASIK operation were used as the treatment group and the patients with non-surgical myopia as the control group. The naked eyesight, diopter and lacrimal film rupture time were examined before and after operation for 1 a, 3 a and 5 years, respectively. Corneal fluorescein staining and tear secretion test were used to diagnose and fill out the ocular surface disease index (OSDI) questionnaire. Results the incidence of dry eye in group A was higher than that in group A (35. 6% before operation) and decreased with time (51.7% 44.9% and 40.7% respectively) and there was no significant difference between two groups at different time points (P 0.05). There was no significant difference before operation (P 0.05), but the other time after operation in group A was higher than that in group B (both P0.05A group accounted for the majority but decreased year by year (65.6% and 41.7%, respectively). The composition of moderate and severe dry eyes increased year by year. The severe dry eyes were more obvious (6.6% and 16.7%, P 0.05%, respectively). 5 years after operation, the OSDI scores of naked eye and visual function in dry eye patients were significantly lower than those in non-dry eyes patients (P 0.05). The OSDI scores of residual diopter and ocular symptoms were significantly higher in dry eye patients than those in non-dry eyes patients (P 0.05). Conclusion the dry eye of young myopia patients may be aggravated after LASIK. It is necessary to pay attention to the progress of dry eye in young myopia patients after LASIK for a long time.
【作者单位】：承德医学院附属医院眼科;
【基金】：河北省科技支撑计划项目(编号:20092084) 河北省自然科学基金面上项目(编号:H2015406054) 河北省政府资助省级临床医学优秀人才项目(编号:361008)~~
【分类号】：R779.63

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