PIK3CA过表达与鼻咽癌发生及预后的关系

发布时间：2018-05-15 10:47

本文选题：鼻咽肿瘤 + 丝氨酸/苏氨酸蛋白激酶　；参考：《临床耳鼻咽喉头颈外科杂志》2017年09期

【摘要】：目的:分析磷脂酰肌醇3-激酶催化亚基α(PIK3CA)过表达与鼻咽癌发生及预后的关系。方法:对正常鼻咽黏膜、癌旁组织以及鼻咽癌组织中丝氨酸/苏氨酸蛋白激酶(pAkt)与PIK3CA的表达状况进行检测,用免疫组织化学方法对其与肿瘤的发展关系进行深入分析;对肿瘤分期、预后与PIK3CA过表达之间的关系进行全面分析。结果:癌旁组织、鼻咽癌组织中pAkt、PIK3CA的表达明显升高(P0.05)。PIK3CA过表达的程度和肿瘤临床分期之间存在显著相关性(T分期:r=0.437,P0.01;N分期:r=0.318,P0.05;临床分期:r=0.496,P0.01)。与PIK3CA表达阴性者相比,PIK3CA表达阳性者有着更差的总生存预后(P0.01)。结论:PIK3CA在鼻咽癌组织中呈现高表达,其与更差的临床分期及总生存预后呈显著相关。
[Abstract]:Aim: to investigate the relationship between the overexpression of phosphatidylinositol 3-kinase catalyzed subunit 伪 -PIK3 CA and the occurrence and prognosis of nasopharyngeal carcinoma. Methods: the expression of serine / threonine protein kinase (PIK3CA) and serine / threonine protein kinase (PIK3CA) in normal nasopharyngeal mucosa, paracancerous tissues and nasopharyngeal carcinoma tissues were detected, and the relationship between serine / threonine protein kinase and tumor development was analyzed by immunohistochemical method. The relationship between tumor staging, prognosis and overexpression of PIK3CA was analyzed. Results: the expression of PIK3CA in paracancerous tissues and nasopharyngeal carcinoma tissues was significantly increased. There was a significant correlation between the overexpression of P0.05A, PIK3CA and the clinical stage of the tumor. There was a significant correlation between the expression of pAktl PIK3CA and the clinical stage of tumor. Compared with the patients with negative PIK3CA expression, the patients with positive expression of PIK3 CA had a worse overall survival prognosis (P 0.01). Conclusion the high expression of PIK3CA in nasopharyngeal carcinoma is significantly correlated with the worse clinical stage and overall survival prognosis.
【作者单位】：三峡大学附属宜昌市第二人民医院肿瘤医院肿瘤放化疗科;
【分类号】：R739.63

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