阻塞性睡眠呼吸暂停低通气综合征患者骨密度及血清OPG、RANKL的变化

发布时间：2018-05-28 04:18

  本文选题：阻塞性睡眠呼吸暂停低通气综合征 + 骨质疏松　； 参考：《中国骨质疏松杂志》2017年09期

【摘要】：目的通过测定阻塞性睡眠呼吸暂停低通气综合征(obstructive sleep apnea hypopnea syndrome,OSAHS)患者骨密度及血清骨保护素(osteoprotegerin,OPG)、核因子κB受体活化因子配体(receptor activator of nuclear factor kappa-B ligand,RANKL)的变化,初步探讨OSAHS与骨质疏松的关系。方法根据呼吸暂停低通气指数(apnea hypopnea index,AHI)将我院确诊的88名OSAHS患者分为3组:轻度组(5次/h≤AHI15次/h)30例、中度组(15次/h≤AHI30次/h)30例、重度组(AHI≥30次/h)28例,并选择30名健康人群作为正常对照组。记录所有受试者一般资料,测定骨代谢指标及腰椎、股骨颈骨密度,采用双抗体夹心酶联免疫吸附法检测各组受试者的血清OPG、RANKL水平,比较各组之间的差异并与AHI进行相关性分析,P0.05为差异有统计学意义。结果中度OSAHS组腰椎、股骨颈骨密度较正常对照组降低,差异有统计学意义;重度OSAHS组腰椎、股骨颈骨密度分别较正常对照组、轻度OSAHS组降低,差异有统计学意义。各组OSAHS患者血清OPG均较正常对照组降低,其中重度OSAHS组分别与轻度OSAHS组、正常对照组差异有统计学意义。各组OSAHS患者血清RNAKL均较正常对照组升高,其中中度OSAHS组较正常对照组差异有统计学意义,重度OSAHS组分别较轻度OSAHS组、正常对照组差异有统计学意义。Pearson相关性分析结果显示:骨密度、OPG与AHI呈负相关,RANKL与AHI呈正相关。结论OSAHS患者有发生骨质疏松的风险,且与缺氧程度密切相关,OPG/RANKL比率下调可能为作用机制之一。
[Abstract]:Objective to determine the changes of bone mineral density (BMD) in patients with obstructive sleep apnea hypopnea syndrome (OSAHS) and the changes of serum osteoprotegerin OPG, nuclear factor- 魏 B receptor activator ligand receptor activator of nuclear factor kappa-B ligand (RANKL) in patients with obstructive sleep apnea hypopnea syndrome (OSAHS), and to explore the relationship between OSAHS and osteoporosis. Methods according to apnea hypopnea index, 88 patients with OSAHS in our hospital were divided into 3 groups: 30 cases of mild group with 5 / h 鈮，

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