不同术式对OSAHS患儿免疫功能的影响

发布时间：2018-06-28 18:57

本文选题：睡眠呼吸暂停低通气综合征 + 阻塞性　；参考：《临床耳鼻咽喉头颈外科杂志》2016年05期

【摘要】：目的:探讨单纯腺样体切除术、腺样体切除伴扁桃体部分切除术、腺样体切除伴扁桃体全部切除术3种术式对OSAHS患儿体液及细胞免疫功能的影响。方法:将经PSG确诊为OSAHS的患儿根据扁桃体肥大程度分为单纯腺样体切除组(A组)、腺样体切除伴扁桃体部分切除组(B组)、腺样体切除伴扁桃体全部切除组(C组),每组50例,分别于术前及术后6个月测定其血清IgG、IgA、IgM水平及外周血T细胞亚群百分率,并于术后6个月时观察扁桃体分级,行多导睡眠监测、记录症状改善情况。结果:3组患儿术后6个月时体液免疫及细胞免疫指标与术前相比差异无统计学意义(P0.05);术后6个月时,3组间疗效比较差异无统计学意义(P0.05)。结论:单纯腺样体切除术、腺样体切除伴扁桃体部分切除术、腺样体切除伴扁桃体全部切除术对患儿的体液及细胞免疫功能无明显影响,均可达到治疗儿童OSAHS的效果。
[Abstract]:Objective: to investigate the effects of adenoidectomy, adenoidectomy with partial tonsillectomy and adenoidectomy with total tonsillectomy on humoral and cellular immune function in children with OSAHS. Methods: children with OSAHS diagnosed by PSG were divided into simple adenoidectomy group (group A), adenoidectomy with partial tonsillectomy group (group B) and adenoidectomy with tonsillectomy group (group C) according to the degree of tonsillectomy. Before and 6 months after operation, the serum IgGG IgA- IgM level and the percentage of T lymphocyte subsets in peripheral blood were measured, and the tonsil grading was observed at 6 months after operation, polysomnography was performed to record the improvement of symptoms. Results there was no significant difference in humoral immunity and cellular immunity between the three groups at 6 months after operation (P0.05), but there was no significant difference in curative effect between the three groups at 6 months after operation (P0.05). Conclusion: simple adenoidectomy, adenoidectomy with partial tonsillectomy and total adenoidectomy with tonsillectomy have no significant effect on humoral and cellular immune function of children.
【作者单位】：山东大学齐鲁医院耳鼻咽喉头颈外科卫生部耳鼻咽喉科学重点实验室;
【基金】：国家自然科学基金资助项目(No:81170903)
【分类号】：R766

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