干性年龄相关性黄斑变性治疗的研究进展
发布时间：2018-08-07 18:34
【摘要】：年龄相关性黄斑变性(age-related macular degeneration,AMD)是60岁以上老年人视力不可逆性损伤的首要原因,其发病率随着年龄的增加而增高。干性AMD是AMD最常见的一种类型,它会引起视力逐渐下降,病情进展非常缓慢,干性AMD病程发展到晚期时,出现地图样萎缩,中心视力也会缺失。目前普遍认为其发病机制主要由慢性炎症损伤、氧化应激损伤、脂褐质沉积及玻璃膜疣形成、脉络膜血供不足等引起,针对病因治疗是当前主要治疗方案,但一些新的治疗方法如番红花酸、姜黄色素、睫状神经营养因子、纳米二氧化铈和人单克隆抗体、光感受器及干细胞移植等目前均用于治疗干性AMD。本文就干性AMD治疗的研究进展进行综述。
[Abstract]:Age-related macular degeneration (age-related macular) is the leading cause of irreversible visual impairment in the elderly over 60 years old, and its incidence increases with the increase of age. Dry AMD is one of the most common types of AMD. It can cause the visual acuity to decline gradually, and the progress of the disease is very slow. In the late stage of dry AMD, atrophic atrophy occurs and the central visual acuity is absent. At present, it is generally believed that its pathogenesis is mainly caused by chronic inflammatory injury, oxidative stress injury, lipofuscin deposition, vitreous warts formation, choroidal blood supply insufficiency and so on. However, some new treatments such as safflower acid, curcumin, ciliary neurotrophic factor, nano-cerium oxide and human monoclonal antibody, photoreceptor and stem cell transplantation are currently used to treat dry AMDs. This article reviews the research progress of dry AMD therapy.
【作者单位】： 重庆医科大学附属第一医院 眼科学重庆重点实验室 重庆市眼科研究所;
【基金】：国家自然科学基金资助(编号:81670881)~~
【分类号】：R774.5
本文编号：2170967
[Abstract]:Age-related macular degeneration (age-related macular) is the leading cause of irreversible visual impairment in the elderly over 60 years old, and its incidence increases with the increase of age. Dry AMD is one of the most common types of AMD. It can cause the visual acuity to decline gradually, and the progress of the disease is very slow. In the late stage of dry AMD, atrophic atrophy occurs and the central visual acuity is absent. At present, it is generally believed that its pathogenesis is mainly caused by chronic inflammatory injury, oxidative stress injury, lipofuscin deposition, vitreous warts formation, choroidal blood supply insufficiency and so on. However, some new treatments such as safflower acid, curcumin, ciliary neurotrophic factor, nano-cerium oxide and human monoclonal antibody, photoreceptor and stem cell transplantation are currently used to treat dry AMDs. This article reviews the research progress of dry AMD therapy.
【作者单位】： 重庆医科大学附属第一医院 眼科学重庆重点实验室 重庆市眼科研究所;
【基金】：国家自然科学基金资助(编号:81670881)~~
【分类号】：R774.5
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