Vogt-小柳-原田综合征黄斑中心凹脉络膜厚度分析

发布时间：2018-08-08 18:47

【摘要】：目的分析Vogt-小柳-原田综合征患者急性期与恢复期黄斑中心凹下方脉络膜厚度(subfoveal choroidal thickness,SFCT)变化。方法 30例Vogt-小柳-原田综合征患者60眼纳入研究,其中男14例,女16例,年龄(45.38±10.19)岁。所有患者均行眼前节检查、最佳矫正视力、眼底彩色照相、眼底血管荧光造影(fundus fluorescein angiography,FFA)及频域光学相干断层扫描(spectral domain optical coherence tomography,SD-OCT)等检查确诊。经糖皮质激素口服治疗前及治疗2周、6个月、12个月后应用SD-OCT对Vogt-小柳-原田综合征患者进行深度加强扫描(enhanced depth imaging,EDI)测量SFCT。与正常同龄人群SFCT值进行比较。结果患眼与正常同龄人群SFCT值(287.85±27.70)μm比较,糖皮质激素治疗前,患眼SFCT厚度(437.46±30.14)μm明显增加,差异有统计学意义(t=3.591,P0.01)。治疗2周后,患眼SFCT厚度为(352.50±60.37)μm,较治疗前显著下降,差异有统计学意义(t=2.567,P0.05)。治疗6个月及12个月后,患眼SFCT厚度分别为(299.32±20.12)μm、(297.61±21.89)μm,与正常人群SFCT值比较,差异均无统计学意义(t=1.362、1.272,均为P0.05)。结论 Vogt-小柳-原田综合征患者急性期SFCT较正常同龄人群明显增厚,恢复期与同龄正常人群比较无明显差别。
[Abstract]:Objective to analyze the changes of (subfoveal choroidal thickness of choroidal thickness under fovea of macular central fovea in patients with Vogt- Xiaoliu-Harada syndrome (Vogt- Xiaoliu-Harada syndrome). Methods Thirty eyes of 30 patients with Vogt- Xiaoliu-Harada syndrome were enrolled in the study, including 14 males and 16 females, aged (45.38 卤10.19) years. All patients were diagnosed by anterior segment examination, best corrected visual acuity, fundus color photography, fundus fluorescein angiography (fundus fluorescein) and frequency-domain optical coherence tomography (spectral domain optical coherence). Before and after oral glucocorticoid treatment for 2 weeks, 6 months and 12 months, SD-OCT was used to measure SFCTs in patients with Vogt- Xiaoliu-Harada syndrome by (enhanced depth imaginging-EDI. The SFCT value of normal peer group was compared with that of normal peer group. Results the SFCT value of the affected eyes was (287.85 卤27.70) 渭 m compared with that of the normal group. Before glucocorticoid treatment, the SFCT thickness of the affected eyes (437.46 卤30.14) 渭 m was significantly increased (t = 3.591P 0.01). After 2 weeks of treatment, the thickness of SFCT in the affected eyes was (352.50 卤60.37) 渭 m, which was significantly lower than that before treatment (P < 0.05). After 6 months and 12 months of treatment, the SFCT thickness of the affected eyes was (299.32 卤20.12) 渭 m and (297.61 卤21.89) 渭 m, respectively. There was no significant difference between the SFCT values of the affected eyes and the normal subjects (t = 1.3621.272, P0.05). Conclusion the SFCT of patients with Vogt- Xiaoliu-Harada syndrome is thicker than that of normal subjects in acute stage, but there is no significant difference between convalescence and normal people of the same age.
【作者单位】：郑州大学第一附属医院眼科;河南科技大学;
【基金】：郑州市技术研究与开发项目基金资助(编号:121PCXTD523)~~
【分类号】：R773.9;R774.5

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