长期口服小剂量克拉霉素干混悬剂治疗儿童慢性鼻-鼻窦炎疗效分析

发布时间：2018-08-09 10:09

【摘要】：目的观察儿童慢性鼻-鼻窦炎(chronic rhinosius-itis,CRS)患儿予以长期小剂量克拉霉素干混悬剂口服效果。方法选取本院2014年1月至2016年1月108例儿童慢性鼻-鼻窦炎患者,予以长期口服小剂量克拉霉素干混悬剂治疗,按照治疗方式的不同将108例患儿分为克拉霉素干混悬剂组(n=54)与对照组(n=54),对于克拉霉素干混悬剂组采用内舒拿喷鼻剂喷鼻和0.9%Nacl进行鼻腔冲洗及口服小剂量克拉霉素干混悬剂进行治疗,对照组采用内舒拿喷鼻剂喷鼻和0.9%Nacl行鼻腔冲洗,对比疗效。每4周为1疗程,共3个疗程。治疗前及每1个疗程后采用视觉模拟量表(visual analog scale,VAS)及Lund-Kennedy评分法评价。结果两组病例经过第1疗程治疗后,其症状VAS总分较治疗前下降(P0.05),鼻内镜评分也较治疗前下降(P0.05),但两组间差异无显著性意义(P0.05),经过第2疗程治疗后,两组病例症状VAS总分和鼻内镜评分均较治疗前和第1疗程后明显下降(P0.01),至第3个疗程后,两组病例症状VAS总分和鼻内镜评分均较治疗前、第1疗程和第2疗程明显下降(P0.01),克拉霉素组疗效明显高于对照治疗组(P0.01)。结论克拉霉素干混悬剂组疗效显著高于常规治疗组。长期小剂量克拉霉素干混悬剂在儿童CRS治疗方案中疗效显著,治疗安全有效。
[Abstract]:Objective to observe the oral effect of low dose clarithromycin dry suspension in children with chronic rhinosis-nasosinusitis (chronic rhinosius-itisus). Methods from January 2014 to January 2016, 108 children with chronic rhinosinusitis were treated with low dose clarithromycin dry suspension for a long time. According to the different treatment methods, 108 children were divided into clarithromycin dry suspension group and control group. For clarithromycin dry suspension group, nasal lavage and oral administration of clarithromycin were performed by nasal spray and 0.9%Nacl and oral administration of clarithromycin. Dry suspension treatment, In the control group, the nasal cavity irrigation was performed with the nasal spray of Neisuna and 0.9%Nacl, and the curative effect was compared. There were 3 courses of treatment every 4 weeks. Visual analogue scale (visual analog scale) and Lund-Kennedy score were used before and after each course of treatment. Results after the first course of treatment, the total score of VAS and the score of nasal endoscopy were decreased (P0.05), but there was no significant difference between the two groups (P0.05). After the second course of treatment, the total score of VAS was lower than that of before treatment (P0.05), but there was no significant difference between the two groups (P0.05). The total score of VAS and the score of nasal endoscopy in both groups were significantly lower than those before treatment and after the first course of treatment (P0.01). After the third course of treatment, the total score of symptom VAS and the score of nasal endoscopy in both groups were higher than those before treatment. The curative effect of clarithromycin group was significantly higher than that of control group (P0.01). Conclusion the curative effect of clarithromycin dry suspension group is higher than that of routine treatment group. Long-term low-dose clarithromycin dry suspension was effective and safe in the treatment of children with CRS.
【作者单位】：广东省河源市妇幼保健院儿科;
【分类号】：R765.41

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