鼻内镜术后布地奈德鼻腔灌洗与鼻腔喷剂治疗慢性鼻-鼻窦炎合并哮喘的比较研究
发布时间：2018-08-18 09:33
【摘要】：目的比较鼻内镜术后采用布地奈德鼻腔灌洗与鼻腔喷剂治疗对慢性鼻-鼻窦炎(CRS)合并哮喘患者的影响。方法对符合条件的48例CRS合并哮喘患者随机分为灌洗组和喷雾组(n=24),灌洗组鼻内镜手术(ESS)后采用0.5 mg布地奈德溶于250 ml生理盐水鼻腔灌洗,喷雾组ESS后采用布地奈德喷雾剂喷鼻。随访1、3及6个月,比较两组治疗前后汉化版鼻腔鼻窦结局测试22条(SNOT-22)、Lund-Kennedy(LK)内镜评分、口服类固醇和吸入类固醇的使用量。结果不同时间SNOT-22和LK内镜评分差异有统计学意义(P=0.000),灌洗组与喷雾组的SNOT-22和LK内镜评分差异有统计学意义(P=0.004和0.009),与喷雾组比较,灌洗组的SNOT-22和LK内镜评分较低,相对效果较好。灌洗组与喷雾组的SNOT-22和LK内镜评分变化趋势差异有统计学意义(P=0.000)。两组间入组后治疗6个月期间口服激素总量比较,差异有统计学意义(P=0.000);两组治疗前后6个月口服激素总量比较,差异有统计学意义(P0.05);两组间及组内术前6个月及治疗后6个月期间使用吸入激素量,差异均无统计学意义(P0.05)。结论 CRS伴哮喘患者ESS后,布地奈德鼻腔灌洗是一种有效的方法,可以改善生活质量,防止复发和减少使用口服类固醇,效果优于鼻腔喷剂。但灌洗后吸入激素量没有减少。
[Abstract]:Objective to compare the effects of budesonide nasal lavage and nasal spray on chronic rhinosinusitis (CRS) patients with asthma after endoscopic surgery. Methods 48 patients with CRS complicated with asthma were randomly divided into two groups: the lavage group and the spray group. The lavage group was treated with 0.5 mg budesonide dissolved in 250ml normal saline nasal cavity after endoscopic (ESS) operation, and the spray group was treated with budesonide spray after ESS. Two groups were followed up for 1 ~ 3 and 6 months. The endoscopic score of Lund-Kennedy (LK), the dosage of oral steroids and inhaled steroids were compared between the two groups before and after treatment in Chinese version of nasal cavity and paranasal sinus outcome test (SNOT-22). Results there were significant differences in SNOT-22 and LK endoscopy scores at different time points (P0. 000), and there were significant differences in SNOT-22 and LK endoscopy scores between lavage group and spray group (P0. 004 and 0.009). Compared with spray group, SNOT-22 and LK endoscopy scores in lavage group were lower and the relative effect was better. There was significant difference in SNOT-22 and LK endoscopy score between lavage group and spray group (P0. 000). There was significant difference in total oral hormone between the two groups during 6 months after treatment (P0. 000), and the total oral hormone before and after treatment in the two groups was higher than that in the control group. The difference was statistically significant (P0.05); there was no significant difference in the amount of inhaled hormone between the two groups before 6 months and 6 months after treatment (P0.05). Conclusion budesonide nasal lavage is an effective method for improving the quality of life, preventing recurrence and reducing the use of oral steroids after ESS in patients with CRS and asthma, and the effect is better than nasal spray. However, the amount of inhaled hormones did not decrease after lavage.
【作者单位】： 湖南省娄底市中心医院耳鼻咽喉头颈外科;中南大学湘雅医院耳鼻咽喉头颈外科;
【分类号】：R765.9
，
本文编号：2189066
[Abstract]:Objective to compare the effects of budesonide nasal lavage and nasal spray on chronic rhinosinusitis (CRS) patients with asthma after endoscopic surgery. Methods 48 patients with CRS complicated with asthma were randomly divided into two groups: the lavage group and the spray group. The lavage group was treated with 0.5 mg budesonide dissolved in 250ml normal saline nasal cavity after endoscopic (ESS) operation, and the spray group was treated with budesonide spray after ESS. Two groups were followed up for 1 ~ 3 and 6 months. The endoscopic score of Lund-Kennedy (LK), the dosage of oral steroids and inhaled steroids were compared between the two groups before and after treatment in Chinese version of nasal cavity and paranasal sinus outcome test (SNOT-22). Results there were significant differences in SNOT-22 and LK endoscopy scores at different time points (P0. 000), and there were significant differences in SNOT-22 and LK endoscopy scores between lavage group and spray group (P0. 004 and 0.009). Compared with spray group, SNOT-22 and LK endoscopy scores in lavage group were lower and the relative effect was better. There was significant difference in SNOT-22 and LK endoscopy score between lavage group and spray group (P0. 000). There was significant difference in total oral hormone between the two groups during 6 months after treatment (P0. 000), and the total oral hormone before and after treatment in the two groups was higher than that in the control group. The difference was statistically significant (P0.05); there was no significant difference in the amount of inhaled hormone between the two groups before 6 months and 6 months after treatment (P0.05). Conclusion budesonide nasal lavage is an effective method for improving the quality of life, preventing recurrence and reducing the use of oral steroids after ESS in patients with CRS and asthma, and the effect is better than nasal spray. However, the amount of inhaled hormones did not decrease after lavage.
【作者单位】： 湖南省娄底市中心医院耳鼻咽喉头颈外科;中南大学湘雅医院耳鼻咽喉头颈外科;
【分类号】：R765.9
，
本文编号：2189066
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