阻塞性睡眠呼吸暂停综合征与抑郁症相关性的调查分析

发布时间：2018-08-21 10:26

【摘要】：过去20年中的临床研究已经表明阻塞性睡眠呼吸暂停综合征（Obstructive SleepApnea Syndrome，OSA）与抑郁症之间存在着密切的关系。近年来，由于人们生活水平的提高，且存在人口老龄化，根据人群年龄、性别和其他人口健康的特点而定，中老年患者存在两种疾病的患病率可能会更高。研究表明：OSA可能会影响超过50%的65岁以上的人口，其中存在显著抑郁症的老年人可能占城市居住人口的26％以上。在临床实践中，随访有抑郁症症状的OSA患者时，只考虑到其治疗方法和治疗反应，另一方面，存在抑郁症的OSA患者很少进行抑郁症的定期评估。然而，OSA不仅与抑郁症的发生有关，而且OSA的存在也可能是抑郁症药物治疗失败的一个重要原因。提高对抑郁症和OSA之间关系的认识，可能会显著改善疾病的诊断准确率以及治疗效果。在本研究中我们将对明确诊断为阻塞性睡眠呼吸暂停综合征的88例患者进行临床资料分析，OSA与抑郁症的相关性及其对临床工作的影响进行讨论。目的：探讨阻塞性睡眠呼吸暂停综合征与抑郁症的相关性。方法：采用描述性研究方法，对2009年9月-2011年5月在吉林大学第一医院呼吸科睡眠实验室经多导睡眠图(Polysomno graphy，PSG)监测确诊的88例阻塞性睡眠呼吸暂停综合征的患者进行调查，主要调查工具有一般情况调查表、Epworth嗜睡量表（EpworthSleepiness Scale，ESS）、Zung抑郁自评量表(Self Rating DepressionScale，SDS)。所收集资料采用Excel建立数据库，，采用SPSS13.0软件进行统计分析。结果：88例OSA患者中抑郁症的发生率为47.7%，明显高于对照组的13.3%。轻、中、重度OSA患者抑郁症的发生率分别为22.7%、44.4%、70.0%。88例OSA中，随着BIM、AHI、ESS得分的升高，夜间SaO2min的降低，抑郁得分越高。结论：1、OSA与抑郁症具有相关性，在OSA患者中抑郁症的发生率随着OSA病情的加重而增加。2、88例OSA中，抑郁得分与BMI、AHI、ESS呈正相关，与最低血氧饱和度呈负相关。3、OSA患者应警惕抑郁症的发生，抑郁症的调查应在OSA患者中常规进行，有助于临床诊断及治疗。
[Abstract]:Clinical studies over the past 20 years have shown a close relationship between obstructive sleep apnea syndrome (Obstructive SleepApnea) and depression. In recent years, due to the improvement of people's living standard and the aging of population, the prevalence of two diseases in middle-aged and elderly patients may be higher according to the characteristics of population age, sex and other population health. Studies show that OSA may affect more than 50 percent of the population over 65, with significant depression likely to account for more than 26 percent of the urban population. In clinical practice, only the treatment and response of OSA patients with depression symptoms are taken into account when following up. On the other hand, OSA patients with depression are rarely evaluated regularly for depression. However, OSA is not only related to the occurrence of depression, but also the existence of OSA may be an important reason for the failure of drug therapy for depression. Raising awareness of the relationship between depression and OSA may significantly improve the diagnostic accuracy and therapeutic effectiveness of the disease. In this study, we will analyze the clinical data of 88 patients with obstructive sleep apnea syndrome (OSAS) and discuss the relationship between OSA and depression and its influence on clinical work. Objective: to investigate the relationship between obstructive sleep apnea syndrome (OSAS) and depression. Methods: from September 2009 to May 2011, 88 patients with obstructive sleep apnea syndrome (OSAS) who were monitored by Polysomno map in the sleep laboratory of Department of Respiratory, first Hospital of Jilin University were investigated by descriptive method. The main survey tools were EpworthSleepiness scale (EpworthSleepiness scale) and Zung self rating Depression scale (Self Rating DepressionScale scale SDS). Excel was used to set up the database and SPSS13.0 software was used for statistical analysis. Results the incidence of depression in 88 OSA patients was 47. 7%, which was significantly higher than that in the control group (13. 3%). The incidence of depression in patients with mild, moderate and severe OSA was 22.74.4and 70.0in 88 cases of OSA. The higher the score of SaO2min was, the higher the score of depression was. Conclusion the incidence of depression in OSA patients increased with the exacerbation of OSA in 88 cases of OSA. The score of depression was positively correlated with BMIAHI ESS. The patients with OSA and the lowest oxygen saturation should be on guard against the occurrence of depression, and the investigation of depression should be carried out routinely in the patients with OSA, which is helpful for clinical diagnosis and treatment.
【学位授予单位】：吉林大学
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R766;R749.4

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