鼻咽癌调强放疗中腮腺平均吸收剂量预测模型研究

发布时间：2018-09-09 14:33

【摘要】：目的探讨鼻咽癌调强放疗时腮腺平均吸收剂量(Dmean)及其D50%的预测模型。方法随机选取西南医科大学附属医院肿瘤科50例鼻咽癌调强放疗患者,采集初始放疗计划CT图像,分析腮腺体积与其Dmean和D50%之间的相关数学模型,在制作放疗计划前对腮腺的Dmean及其D50%进行预测。结果鼻咽癌患者Voverlap/Vparotid与Dmean/Dprescription之间存在显著正相关性(置信度为0.01,r=0.895),Voverlap/Vparotid与D50%/Dprescription之间存在显著正相关性(置信度为0.01,r=0.812),并利用Matlab软件拟合出上述两者之间的相关公式。结论鼻咽癌患者在制作放疗计划前可根据本研究所拟合出的相关数学模型,在给定处方条件下通过Voverlap/Vparotid,提前预测出Dmean与D50%,作为调强计划评估标准,从而减少放疗计划优化过程中主观因素造成的影响。
[Abstract]:Objective to study the predictive model of mean absorbed dose of parotid gland (Dmean) and D 50% during intensity-modulated radiotherapy for nasopharyngeal carcinoma (NPC). Methods 50 patients with nasopharyngeal carcinoma were randomly selected from Department of Oncology, affiliated Hospital of Southwest Medical University. The CT images of initial radiotherapy plan were collected and the correlation mathematical models between parotid volume and Dmean and D 50% were analyzed. Dmean and D 50% of parotid gland were predicted before radiotherapy. Results there was a significant positive correlation between Voverlap/Vparotid and Dmean/Dprescription in nasopharyngeal carcinoma patients (confidence degree was 0.01rr = 0.895). There was a significant positive correlation between Voverlap-Vparotid and D50%/Dprescription (confidence degree was 0.01rr 0.812), and the correlation formula between Voverlap-Vparotid and D50%/Dprescription was fitted by Matlab software. Conclusion before making radiotherapy plan, nasopharyngeal carcinoma patients can predict Dmean and D50 in advance through Voverlap/Vparotid, under the given prescription condition according to the mathematical model fitted by this study, which can be used as the evaluation standard of intensity modulation plan. In order to reduce the impact of subjective factors in the optimization of radiotherapy plan.
【作者单位】：西南医科大学附属医院肿瘤科;
【分类号】：R739.63

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