长期小剂量克拉霉素治疗慢性鼻-鼻窦炎的疗效观察

发布时间：2018-09-09 14:31

【摘要】：目的观察长期小剂量克拉霉素治疗慢性鼻-鼻窦炎的疗效。方法将93例慢性鼻-鼻窦炎(不伴鼻息肉)患者,随机分为两组,治疗组46例,对照组47例,治疗组采用克拉霉素250mg口服,1次/d,联合鼻用糖皮质激素、黏液促排剂及生理性海水鼻腔盥洗。对照组则单纯采用鼻用糖皮质激素、黏液促排剂及生理性海水鼻腔盥洗。治疗前后采用视觉模拟量表评分(visual analogue scale,VAS)、鼻窦CT评分(Lund Mackay)及临床疗效进行疗效评价。结果两组治疗3个月后的VAS评分、鼻窦CT评分和临床疗效评定均降低,差异有统计学意义(P0.05)。治疗组较对照组降低更明显,差异有统计学意义(P0.05)。且在整个治疗期间未发现患者有任何严重的不良反应。结论长期小剂量克拉霉素联合鼻用糖皮激素、黏液促排剂及生理性海水鼻腔盥洗治疗慢性鼻-鼻窦炎临床疗效好。
[Abstract]:Objective to observe the effect of long-term low-dose clarithromycin on chronic rhinosinusitis. Methods 93 patients with chronic rhinosinusitis (without nasal polyps) were randomly divided into two groups: treatment group (n = 46) and control group (n = 47). The treatment group was treated with clarithromycin 250mg once a day, combined with glucocorticoid. Mucus draining agent and physiologic sea water nasal lavatory. The control group was treated with nasal glucocorticoid, mucus discharges and physiologic sea water nasal lavatory. Visual analogue scale (visual analogue scale,VAS), paranasal sinus CT score (Lund Mackay) and clinical efficacy were used before and after treatment. Results after 3 months of treatment, the VAS score, sinus CT score and clinical efficacy of the two groups were significantly lower than those of the control group (P0.05). The treatment group was significantly lower than the control group, the difference was statistically significant (P0.05). No serious adverse reactions were found throughout the treatment. Conclusion Long-term low dose clarithromycin combined with glucocorticoid mucus and physiologic seawater nasal lavage is effective in the treatment of chronic rhinosinusitis.
【作者单位】：武汉市汉口医院耳鼻咽喉科;
【分类号】：R765

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