同步放化疗与单纯放疗对鼻咽癌患者近期及远期影响

发布时间：2018-10-10 17:34

【摘要】：目的:探讨同步放化疗与单纯放疗对鼻咽癌患者近期及远期影响。方法:选取我院2008年2月至2010年2月的156例鼻咽癌患者进行研究,随机分为同步放化疗组和单纯放疗组各78例,同步放化疗组采用奥沙利铂联合贝伐单抗与卡培他滨化疗2周期再进行放疗,单纯放疗组采用顺铂单纯放疗,观察两组患者的治疗效果,1、3、5年的生存率和局部控制率,并发症等指标。结果:同步放化疗组的有效率(92.3%)明显高于单纯放疗组(79.5%),具有统计学意义(χ~2=5.987,P0.05);同步化放疗组1、3、5年的局部控制率(76.9%、62.8%、48.7%)明显高于单纯放疗组(62.8%、48.7%、38.5%),具有统计学意义(χ~2=5.696,P=0.031;χ~2=5.595,P=0.032;χ~2=5.512,P=0.039);同步化放疗组的1、3、5年的生存率(66.7%、56.4%、46.2%)明显高于单纯放疗组(56.4%、46.2%、35.9%),具有统计学意义(χ~2=5.396,P=0.033;χ~2=5.356,P=0.034;χ~2=5.445,P=0.031);同步化放疗组的并发症发生率(5.1%)明显低于单纯放疗组(28.2%),具有统计学意义(χ~2=5.968,P0.05)结论:对鼻咽癌患者进行同步化放疗能更好的控制病情,提高患者的生存率,减少不良反应的发生,比较安全。
[Abstract]:Objective: to investigate the short-term and long-term effects of concurrent radiotherapy and radiotherapy alone on nasopharyngeal carcinoma (NPC) patients. Methods: 156 patients with nasopharyngeal carcinoma from February 2008 to February 2010 in our hospital were randomly divided into simultaneous radiotherapy and chemotherapy group (n = 78) and radiotherapy alone group (n = 78). The concurrent radiotherapy group was treated with oxaliplatin combined with bevacizumab and capecitabine chemotherapy for 2 cycles, while the radiotherapy group was treated with cisplatin alone. The therapeutic effect, survival rate of 1 and 5 years and local control rate were observed. Complications and other indicators. Results: the effective rate of simultaneous radiotherapy and chemotherapy group (92.3%) was significantly higher than that of radiotherapy group (79.5%), which had statistical significance (蠂 ~ 25.987%), and the local control rate of 5 years (76.9%) was significantly higher than that of radiotherapy group (68.7%), which had statistical significance (蠂 ~ 25.696P 0.031; 蠂 ~ 25.595P 0.032; ~ 25.512P 0.039); and radiotherapy by synchronous radiotherapy (蠂 ~ 25.696P 0.031; 蠂 ~ 25.595P 0.032; ~ 25.512p 0.039). The total effective rate of radiotherapy group was 92.3%, which was significantly higher than that of radiotherapy alone group (79.5%) (蠂 ~ 25.696P 0.031; 蠂 ~ 25.595P 0.032; ~ 25.512p 0.039). The survival rate (66.7v / 56.4g / 56.42%) was significantly higher than that of radiotherapy alone (56.46.2g / 35.9%), and had statistical significance (蠂 ~ 25.396p 0.033; 蠂 ~ 2n 5.356n P 0.034; 蠂 ~ 25.445P 0.031); the incidence of complications in the simultaneous radiotherapy group (5.1%) was significantly lower than that in the radiotherapy group (28.2%), which had statistical significance (蠂 ~ 25.985 P 0.05) conclusion: the incidence of complications in the concurrent radiotherapy group was significantly lower than that in the radiotherapy alone group (28.2%) (蠂 ~ 25.368 P 0.05), and the incidence of complications in the concurrent radiotherapy group was significantly lower than that in the radiotherapy alone group (28.2%) (蠂 ~ 25.368 P 0.05). Simultaneous chemotherapy can better control the condition. It is safe to improve the survival rate and reduce the incidence of adverse reactions.
【作者单位】：中国人民解放军福州总院九五临床部耳鼻咽喉科;中国人民解放军福州总院耳鼻咽喉科;
【基金】：福建省自然科学基金计划项目2012年度省拥军科技重点项目(2012Y5007);福建省自然科学基金计划项目(2013J0396)~~
【分类号】：R739.63

【相似文献】