变应性鼻炎患者外周血嗜酸粒细胞及IL-33水平的表达
发布时间：2018-10-13 11:32
【摘要】：目的:探讨变应性鼻炎(AR)患者外周血嗜酸粒细胞(EOS)计数与IL-33水平的关系及未经任何治疗的AR患者(A组)、经皮下免疫治疗至少1年后AR患者(B组)、经皮下免疫治疗至少1年后伴变应性哮喘(AA)的AR患者(C组)这3组的IL-33水平、嗜酸粒细胞计数、视觉模拟评分(VAS)的关系。方法:选取20例健康者作为对照组参与实验,所有受试者行血细胞分析,统计嗜酸粒细胞数量。采用酶联免疫(ELISA)检测外周血IL-33水平,所得数据用GraphPad.Prism 5.0与SPSS 22.0处理。AR患者行VAS评分并评估鼻部症状。结果:A组IL-33水平高于其他组IL-33水平(P0.05);B组IL-33水平与C组IL-33水平相比,差异无统计学意义(P0.05);B组和C组IL-33水平均高于对照组IL-33水平(P0.05);A组嗜酸粒细胞计数高于其他组,各组间相互比较嗜酸粒细胞计数差异无统计学意义(P0.05);A组VAS评分高于B组VAS评分(P0.05);A组VAS评分与C组VAS评分比较差异无统计学意义(P0.05);B组VAS评分与C组VAS评分比较差异无统计学意义(P0.05)。经皮下免疫治疗(SCIT)至少1年后AR患者自觉鼻塞、流清涕、打喷嚏等症状均有明显减轻。Spearman检验AR患者IL-33水平与嗜酸粒细胞计数呈弱正相关(P0.05,r=0.287)。结论:SCIT对AR疗效明显,可缓解患者临床症状,还可降低患者IL-33水平和外周血嗜酸粒细胞计数。
[Abstract]:Objective: to investigate the relationship between eosinophil (EOS) count and IL-33 level in peripheral blood of patients with allergic rhinitis (AR) and the patients with AR without any treatment (group A), AR patients (group B) after subcutaneous immunotherapy for at least one year, and subcutaneous immunotherapy. At least a year later, the IL-33 levels in the three groups of AR patients with allergic asthma with (AA) (group C), The relationship between eosinophil count and visual analogue score (VAS). Methods: 20 healthy subjects were selected as control group. All subjects were analyzed with blood cells to count the number of eosinophils. The level of IL-33 in peripheral blood was detected by Elisa (ELISA). The data were treated with GraphPad.Prism 5.0 and SPSS 22.0. VAS score and nasal symptoms were evaluated in AR patients. Results: the level of IL-33 in group A was higher than that in other groups (P0.05 IL-33 level in); B group was higher than IL-33 level in C group (P0.05) IL-33 level in); B group and C group was higher than that in control group (P05); A group was higher than other groups in eosinophil count. There was no significant difference in eosinophil count between each group (P0.05); A group VAS score was higher than B group VAS score (P0.05); A group VAS score and C group VAS score difference was not statistically significant (P0.05); B group VAS score and C group VAS score comparison no significant difference (P0.05). After subcutaneous immunotherapy for at least one year, the symptoms of AR patients such as nasal obstruction, snot and sneezing were significantly alleviated. Spearman test showed a weak positive correlation between IL-33 level and eosinophil count in AR patients (P 0.05 rr 0.287). Conclusion: SCIT is effective in treating AR. It can relieve clinical symptoms, decrease IL-33 level and eosinophil count in peripheral blood.
【作者单位】： 广西中医药大学研究生学院;广西壮族自治区人民医院耳鼻咽喉科;
【基金】：国家自然科学基金资助项目(No:81460097) 广西自然科学基金(No:2017JJA140333Z) 广西壮族自治区卫生厅自筹经费科研课题(No:Z2016643)
【分类号】：R765.21
本文编号：2268462
[Abstract]:Objective: to investigate the relationship between eosinophil (EOS) count and IL-33 level in peripheral blood of patients with allergic rhinitis (AR) and the patients with AR without any treatment (group A), AR patients (group B) after subcutaneous immunotherapy for at least one year, and subcutaneous immunotherapy. At least a year later, the IL-33 levels in the three groups of AR patients with allergic asthma with (AA) (group C), The relationship between eosinophil count and visual analogue score (VAS). Methods: 20 healthy subjects were selected as control group. All subjects were analyzed with blood cells to count the number of eosinophils. The level of IL-33 in peripheral blood was detected by Elisa (ELISA). The data were treated with GraphPad.Prism 5.0 and SPSS 22.0. VAS score and nasal symptoms were evaluated in AR patients. Results: the level of IL-33 in group A was higher than that in other groups (P0.05 IL-33 level in); B group was higher than IL-33 level in C group (P0.05) IL-33 level in); B group and C group was higher than that in control group (P05); A group was higher than other groups in eosinophil count. There was no significant difference in eosinophil count between each group (P0.05); A group VAS score was higher than B group VAS score (P0.05); A group VAS score and C group VAS score difference was not statistically significant (P0.05); B group VAS score and C group VAS score comparison no significant difference (P0.05). After subcutaneous immunotherapy for at least one year, the symptoms of AR patients such as nasal obstruction, snot and sneezing were significantly alleviated. Spearman test showed a weak positive correlation between IL-33 level and eosinophil count in AR patients (P 0.05 rr 0.287). Conclusion: SCIT is effective in treating AR. It can relieve clinical symptoms, decrease IL-33 level and eosinophil count in peripheral blood.
【作者单位】： 广西中医药大学研究生学院;广西壮族自治区人民医院耳鼻咽喉科;
【基金】：国家自然科学基金资助项目(No:81460097) 广西自然科学基金(No:2017JJA140333Z) 广西壮族自治区卫生厅自筹经费科研课题(No:Z2016643)
【分类号】：R765.21
【相似文献】
相关期刊论文 前5条
1 张克,张志超,彭金娥,孙红;常年性变应性鼻炎鼻腔嗜酸粒细胞及嗜碱性细胞的观察[J];北京医学;1992年04期
2 曹平平;华小阳;刘争;褚汉启;崔永华;;CRSsNP中肥大细胞及其与嗜酸粒细胞炎症的关系[J];临床耳鼻咽喉头颈外科杂志;2010年20期
3 徐明;赵枫;沈安民;周浩杰;;嗜酸粒细胞型鼻息肉患者血清特异性IgE检测的临床分析[J];临床耳鼻咽喉头颈外科杂志;2012年17期
4 赵长青,陶正德,肖健云,赵素萍,杨平常,孙本韬,乔健天;变应性鼻炎鼻粘膜嗜酸粒细胞脱颗粒透射电镜观察[J];中华耳鼻咽喉科杂志;1997年02期
5 林欣然;李杰恩;;嗜酸粒细胞在慢性鼻-鼻窦炎发病机制中的作用[J];医学综述;2007年14期
相关博士学位论文 前1条
1 廖波;TSLP，IL-33及其受体在嗜酸粒细胞性伴有鼻息肉的慢性鼻—鼻窦炎上皮细胞中的相互作用[D];华中科技大学;2015年
相关硕士学位论文 前1条
1 杨春;嗜酸粒细胞性慢性鼻-鼻窦炎的分型及临床特征研究[D];吉林大学;2017年
，本文编号：2268462
本文链接：https://www.wllwen.com/yixuelunwen/wuguanyixuelunwen/2268462.html
最近更新
教材专著
