润明汤联合人工泪液治疗气阴两虚型干眼临床疗效观察

发布时间：2018-10-15 10:04

【摘要】：目的:评估中药汤剂润明汤联合人工泪液治疗干眼的临床疗效,探寻持久有效的治疗气阴两虚型干眼的方法。材料与方法:本试验收集2016年7月到2016年12月就诊于沈阳何氏眼科医院符合干眼诊断标准的64例(128只眼)患者,中医辨证属于气阴两虚型。采用随机对照的实验方法,将64例(128只眼)患者随机分成治疗组32例(64只眼)和对照组32例(64只眼)。治疗组采用院内制剂润明汤水煎服,日两次口服,每次100ml,同时联合人工泪液(聚乙二醇滴眼液),日5次点双眼。对照组单纯人工泪液(聚乙二醇滴眼液),日5次点双眼。分别观察治疗前、治疗后4周干眼相关评价指标(干眼主观症状评分、SIt、BUT、FL)。结果:1、治疗4周后,治疗组总体有效率为90.32%,明显高于对照组的76.67%,差异有统计学意义(P0.05)。2、治疗4周后,两组干眼患者主观症状总评分及各项评分、角膜荧光素染色评分较治疗前有所降低(P0.01);治疗组SIt、BUT较治疗前有所增加(P0.01);对照组BUT较治疗前有所增加(P0.01),SIt与治疗前比较无统计学差异(P0.05)。3、治疗4周后,治疗组干眼主观症状(干涩感、视疲劳、异物感)评分降低程度、SIt、BUT增加量均优于对照组(P0.05)。4、治疗4周后,治疗组与对照组干眼主观症状(眼红、眼痛)评分、FL评分降低程度无统计学差异(P0.05)。结论:单纯人工泪液(聚乙二醇滴眼液)治疗干眼以及润明汤联合人工泪液治疗干眼均能在一定程度上改善患者的主观症状以及客观指标,但联合治疗组效果明显优于单纯人工泪液组,能从根本上缓解干眼患者的不适症状。
[Abstract]:Objective: to evaluate the clinical efficacy of Runming decoction combined with artificial tear in the treatment of dry eyes and to explore a lasting and effective method for treating dry eyes with deficiency of Qi and Yin. Materials and methods: from July 2016 to December 2016, 64 patients (128 eyes) who met the criteria of dry eye diagnosis in Shenyang Ho's Eye Hospital were collected. 64 patients (128 eyes) were randomly divided into treatment group (n = 32, n = 64) and control group (n = 32, n = 64). In the treatment group, hospital preparation Runming decoction was taken twice a day, 100ml per time, combined with artificial tear (polyethylene glycol eye drops), 5 times a day point eyes. In the control group, artificial tears (polyethylene glycol eye drops) were used five times a day. The relative indexes of dry eye (dry eye subjective symptom score, SIt,BUT,FL) were observed before and 4 weeks after treatment. Results: 1. After 4 weeks of treatment, the total effective rate of the treatment group was 90.32, which was significantly higher than that of the control group (76.67), the difference was statistically significant (P0.05). After 4 weeks of treatment, the total score of subjective symptoms and the scores of the two groups were higher than that of the control group. Corneal fluorescein staining score was lower than that before treatment (P0.01), SIt,BUT in treatment group was higher than that before treatment (P0.01), BUT in control group was higher than that before treatment (P0.01), SIt was not significantly different from that before treatment (P0.05). 3. After 4 weeks of treatment, the subjective symptoms of dry eye in treatment group were dry and astringent. Visual fatigue, foreign body sensation) score decreased, SIt,BUT increased better than the control group (P0.05). 4 weeks after treatment, the treatment group and control group dry eye subjective symptoms (eye red, eye pain) score, FL score decreased no significant difference (P0.05). Conclusion: the treatment of dry eye with pure artificial tear (polyethylene glycol eye drops) and Runming decoction combined with artificial tear can improve the subjective symptoms and objective indexes of the patients to some extent. But the effect of combined treatment was better than that of artificial tear group, which could relieve the uncomfortable symptoms of dry eye patients.
【学位授予单位】：辽宁中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R777.34

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