多西他赛联合顺铂诱导化疗后三维适形调强放疗同步化疗对局部晚期鼻咽癌的疗效分析

发布时间：2018-10-22 07:28

【摘要】：目的观察多西他赛联合顺铂诱导化疗后三维适形调强放疗同步化疗对局部晚期鼻咽癌的疗效。方法300例局部晚期鼻咽癌患者随机分为同步放化疗组(CCRT)和诱导化疗加同步放化疗组(ICCRT),ICCRT组先进行2个周期的多西他赛联合顺铂诱导化疗后再进行同步放化疗,CCRT组仅进行2个周期的多西他赛联合顺铂化疗,在此基础上,所有患者均进行三维适形调强放疗。比较两组患者近期疗效、局部控制率、无转移生存率、不良反应及相关功能。结果ICCRT组患者的近期疗效、局部控制率、无转移生存率、生理评分和生活质量评分均高于CCRT组患者,差异具有统计学意义(P0.05)。ICCRT组和CCRT组均出现不同程度放射性食管炎、放射性肺炎、中性粒细胞减少、血红蛋白减少、恶心呕吐、口腔黏膜反应等,但差异无统计学意义(P0.05)。结论多西他赛与顺铂的联合诱导化疗后同步放化疗治疗局部晚期鼻咽癌可明显提高临床疗效、局部控制率、无转移生存率,不良反应较轻,是治疗局部晚期鼻咽癌的可行方案。
[Abstract]:Objective to observe the efficacy of docetaxel combined with cisplatin induced three dimensional conformal intensity modulated radiotherapy (IMRT) in the treatment of locally advanced nasopharyngeal carcinoma (NPC). Methods 300 patients with locally advanced nasopharyngeal carcinoma were randomly divided into two groups: (CCRT) group and (ICCRT), ICCRT group. Two cycles of docetaxel combined with cisplatin induced chemotherapy were performed before concurrent radiotherapy and chemotherapy in CCRT group. Two cycles of docetaxel combined with cisplatin chemotherapy, On this basis, all patients underwent three-dimensional conformal intensity modulated radiotherapy. The short-term curative effect, local control rate, metastasis-free survival rate, adverse reaction and related function were compared between the two groups. Results the short-term curative effect, local control rate, metastasis-free survival rate, physiological score and quality of life score in ICCRT group were higher than those in CCRT group. The difference was statistically significant (P0.05 between). ICCRT group and CCRT group). Radiation pneumonia, neutropenia, hemoglobin, nausea and vomiting, oral mucosal reaction, but the difference was not statistically significant (P0.05). Conclusion the combination of docetaxel and cisplatin in the treatment of locally advanced nasopharyngeal carcinoma can significantly improve the clinical efficacy, local control rate, metastasis-free survival rate and mild adverse reaction. It is a feasible method for the treatment of locally advanced nasopharyngeal carcinoma.
【作者单位】：广西壮族自治区梧州市红十字会医院;
【分类号】：R739.63

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