不同类型弱视儿童立体视皮层的功能磁共振研究

发布时间：2018-10-23 07:26

【摘要】：目的应用血氧水平依赖的功能磁共振(Blood oxygen level dependent-function magnetic resonance imaging, BOLD-fMRI)技术,研究屈光性弱视患儿立体视皮层功能特点,对比比较屈光不正性弱视与屈光参差性弱视之间脑皮层的激活差异及特点。方法初诊弱视患儿11例,其中屈光不正性患儿5例(2男3女,平均8±1.5岁),屈光参差性患儿6例(4男2女,平均9±2岁)。所有被试均为远视性弱视,中心凹注视；均为右利手；所有被试无局部及全身特殊病史。试验前充分矫正屈光不正；规范化弱视训练后1周及4周时复查fMRI。通过E-Prime2.0软件编写视觉刺激任务程序,刺激模式为对比度接近80%的红蓝立体图像,以SIEMENS MAGNETOM Verio3.0T磁共振扫描系统,分别采集弱视儿童BOLD-fMRI数据。采用SPM8软件包对图像进行处理及分析。比较1.不同时期弱视儿童脑皮层激活差异；2.不同时期屈光不正性弱视组与屈光参差性弱视组间视皮层激活强度及范围的差异变化特点。结果1.当设定P值为0.001,激活范围阈值为10个体素时,屈光性弱视患儿双眼的兴奋区域为以枕叶为中心的视觉皮层,其中以BA18/19/17区皮层激活程度最显著；随训练时间延长,弱视组立体视皮层功能活动范围及活动强度均有所增强。2.当设定P值为0.05,激活范围阈值为10个体素时进行组间比较时,屈光不正性弱视相关视皮层神经元活动水平及激活范围均较屈光参差性弱视有所增加,主要集中在额叶(BA6/BA9/BA10区)、顶叶后部(BA40/BA7区)。结论 1、立体视觉的形成涉及多个脑区,主要位于枕叶,尤以BA17区、BA18区、BA19区为著； 2、随弱视时间的延长,弱视患者立体视皮层活动强度及范围增强； 3、屈光参差性弱视与屈光不正性弱视立体视较易受到损害。
[Abstract]:Objective to study the functional characteristics of stereopsis cortex in children with refractive amblyopia by using functional magnetic resonance (Blood oxygen level dependent-function magnetic resonance imaging, BOLD-fMRI) technique of blood oxygen level dependent. To compare the difference and characteristics of cerebral cortex activation between ametropia amblyopia and anisometropia amblyopia. Methods 11 cases of amblyopia were diagnosed, including 5 cases of ametropia (2 males, 3 females, mean 8 卤1.5 years) and 6 cases of anisometropia (4 males, 2 females, mean 9 卤2 years). All subjects were hyperopic amblyopia, central foveal fixation, right handedness. All subjects had no special history of local and systemic diseases. Full correction of ametropia before trial; fMRI. reexamination at 1 and 4 weeks after standardized amblyopia training The task program of visual stimulation was compiled by E-Prime2.0 software. The stimulation mode was red and blue stereoscopic images with contrast of nearly 80%. BOLD-fMRI data of amblyopic children were collected by SIEMENS MAGNETOM Verio3.0T magnetic resonance scanning system. The image is processed and analyzed by SPM8 software package. Comparison 1. The activation of cerebral cortex in amblyopic children at different stages was different. The changes of the activation intensity and range of visual cortex between ametropia amblyopia group and anisometropia amblyopia group at different periods. Result 1. When P value was 0.001 and the threshold of activation was 10 individual elements, the excitatory area of the eyes of the children with refractive amblyopia was occipital cortex, and the activation degree of the cortex in the BA18/19/17 area was the most significant. The range and intensity of stereoscopic visual cortex activity in amblyopia group were increased. 2. 2. When the P value was 0.05 and the threshold of activation range was 10 individual elements, the activity level and activation range of anisometropic amblyopia related neurons were increased compared with that of anisometropia amblyopia. Mainly concentrated in frontal lobe (BA6/BA9/BA10 area), posterior parietal lobe (BA40/BA7 area). Conclusion (1) the formation of stereoscopic vision involves many brain regions, mainly located in the occipital lobe, especially in the BA17, BA18 and BA19 areas, 2, with the prolongation of amblyopia time, the intensity and range of stereoscopic cortex activity in amblyopic patients are enhanced. 3, anisometropia amblyopia and ametropia amblyopia stereopsis are more easily damaged.
【学位授予单位】：兰州大学
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R777.44

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