探讨布地奈德治疗变应性鼻炎患者后鼻分泌物嗜酸粒细胞与肺功能的相关性

发布时间：2018-10-31 13:16

【摘要】：目的:探讨变应性鼻炎(AR)患者鼻用布地奈德治疗后嗜酸粒细胞(EOS)与肺功能的相关性。方法:按照标准选取50例中重度AR患者(AR组),50例正常者(对照组),对2组行肺功能及鼻分泌物EOS检查。AR组采用布地奈德+氯雷他定治疗3个月后再次行肺功能及EOS检查,分析两者之间的变化趋势。结果:AR组患者EOS均较对照组升高(P0.05),且肺功能最大呼气中期流量(MMEF)与鼻分泌物EOS呈负相关(r=-0.945);治疗后AR患者EOS较治疗前降低,差异有统计学意义(P0.05)。经布地奈德治疗后,AR组患者EOS下降与肺功能上升的数值变化呈正相关(r=0.803)。结论:AR患者鼻分泌物EOS越高,其肺功能下降越明显,经治疗后,AR患者鼻分泌物EOS下降越多,其肺功能改善越大。
[Abstract]:Aim: to investigate the correlation between eosinophil (EOS) and lung function in patients with allergic rhinitis (AR) after budesonide treatment. Methods: 50 patients with moderate and severe AR (AR group) and 50 normal subjects (control group) were selected according to the standard. Pulmonary function and nasal secretions were examined by EOS in two groups, and lung function and EOS were examined again in AR group after 3 months of budesonide loratadine therapy, and the change trend between them was analyzed. Results: EOS in AR group was significantly higher than that in control group (P0.05), and the maximal expiratory flow (MEF) (MMEF) was negatively correlated with nasal secretion EOS (r-0.945). After treatment, the EOS of AR patients was lower than that before treatment, the difference was statistically significant (P0.05). After budesonide treatment, there was a positive correlation between the decrease of EOS and the increase of pulmonary function in AR group (r = 0.803). Conclusion: the higher the EOS of nasal secretions in AR patients, the more obvious the decrease of pulmonary function. After treatment, the more EOS in nasal secretions of AR patients is decreased, the greater the improvement of pulmonary function is.
【作者单位】：青岛经济技术开发区第一人民医院耳鼻咽喉科;青岛大学医学院附属医院耳鼻咽喉科;
【分类号】：R765.21

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