雷珠单抗预防伴有虹膜新生血管的糖尿病视网膜病变术后再出血疗效观察
发布时间：2018-11-05 08:46
【摘要】：目的研究雷珠单抗预防伴有虹膜新生血管的糖尿病视网膜病变玻璃体切割术后再出血的疗效。方法回顾性分析2009年至2015年在我院因糖尿病视网膜病变行玻璃体切割术后出现虹膜新生血管的患者70例(70眼)的临床资料。对照组30例(30眼)行全视网膜激光光凝,多次玻璃体手术、睫状体冷冻等治疗,研究组40例(40眼)术前玻璃体内注射雷珠单抗0.5 mg后联合各项治疗,随访3个月,对比分析两组患者视力、眼压、新生血管消退及并发症等情况。结果术后1个月、2个月时,研究组视力优于对照组,但随着时间的延长,两组视力无明显差异。研究组、对照组术前眼压分别为(26.312±4.566)mmHg(1 kPa=7.5 mmHg)、(25.586±5.783)mmHg,两组相比差异无统计学意义(P=0.687);随访期末眼压分别为(18.576±4.762)mmHg、(28.587±7.786)mmHg,两组相比差异有统计学意义(P=0.041)。对照组术中、术后出现前房和(或)玻璃体积血者分别为12例、5例,研究组为3例、1例,两组术中、术后积血比例相比差异均有统计学意义(均为P=0.000)。随访期末研究组3眼(7.5%)进展为新生血管性青光眼,对照组为10眼(33.3%),两组相比差异有统计学意义(P0.05)。结论糖尿病视网膜病变术后伴有虹膜新生血管时,雷珠单抗可以有效消除新生血管,减少新生血管性青光眼的发生率,并减少前房、玻璃体积血的发生率,在一定时间内有效提高患者视力。
[Abstract]:Objective to study the effect of Leizhu McAb on preventing rebleeding after vitrectomy for diabetic retinopathy with iris neovascularization. Methods the clinical data of 70 patients (70 eyes) with iris neovascularization after vitrectomy in our hospital from 2009 to 2015 were retrospectively analyzed. 30 cases (30 eyes) in the control group were treated with laser photocoagulation, multiple vitreous surgery and ciliary body freezing. 40 cases (40 eyes) in the study group received intravitreous injection of Lei Zhu McAb 0.5 mg before operation and were followed up for 3 months. Visual acuity, intraocular pressure, neovascularization and complications were compared between the two groups. Results the visual acuity of the study group was better than that of the control group at 1 and 2 months postoperatively, but there was no significant difference in visual acuity between the two groups with the prolongation of time. In the study group, intraocular pressure (IOP) in the control group was (26.312 卤4.566) mmHg (1 kPa=7.5 mmHg), (25.586 卤5.783) mmHg, before operation respectively. There was no significant difference between the two groups (P < 0. 687). Intraocular pressure (IOP) was (18.576 卤4.762) mmHg, (28.587 卤7.786) mmHg, at the end of follow-up. In the control group, there were 12 cases and 5 cases of anterior chamber and / or vitreous hemorrhage in the control group, 3 cases in the study group and 1 case in the study group. There was significant difference between the two groups in the proportion of postoperative hemorrhage (P 0.000). At the end of follow-up, 3 eyes (7.5%) developed neovascular glaucoma in the study group and 10 eyes (33.3%) in the control group. The difference between the two groups was statistically significant (P0.05). Conclusion when diabetic retinopathy is associated with iris neovascularization after operation, Lei Zhu McAb can effectively eliminate neovascularization, reduce the incidence of neovascular glaucoma, and reduce the incidence of volume blood in anterior chamber and glass. Improve the visual acuity of patients effectively in a certain time.
【作者单位】： 南昌大学第二附属医院眼科;南昌大学第一附属医院血液内科;
【基金】：国家自然科学基金资助(编号:81460088)~~
【分类号】：R587.2;R779.6
本文编号：2311552
[Abstract]:Objective to study the effect of Leizhu McAb on preventing rebleeding after vitrectomy for diabetic retinopathy with iris neovascularization. Methods the clinical data of 70 patients (70 eyes) with iris neovascularization after vitrectomy in our hospital from 2009 to 2015 were retrospectively analyzed. 30 cases (30 eyes) in the control group were treated with laser photocoagulation, multiple vitreous surgery and ciliary body freezing. 40 cases (40 eyes) in the study group received intravitreous injection of Lei Zhu McAb 0.5 mg before operation and were followed up for 3 months. Visual acuity, intraocular pressure, neovascularization and complications were compared between the two groups. Results the visual acuity of the study group was better than that of the control group at 1 and 2 months postoperatively, but there was no significant difference in visual acuity between the two groups with the prolongation of time. In the study group, intraocular pressure (IOP) in the control group was (26.312 卤4.566) mmHg (1 kPa=7.5 mmHg), (25.586 卤5.783) mmHg, before operation respectively. There was no significant difference between the two groups (P < 0. 687). Intraocular pressure (IOP) was (18.576 卤4.762) mmHg, (28.587 卤7.786) mmHg, at the end of follow-up. In the control group, there were 12 cases and 5 cases of anterior chamber and / or vitreous hemorrhage in the control group, 3 cases in the study group and 1 case in the study group. There was significant difference between the two groups in the proportion of postoperative hemorrhage (P 0.000). At the end of follow-up, 3 eyes (7.5%) developed neovascular glaucoma in the study group and 10 eyes (33.3%) in the control group. The difference between the two groups was statistically significant (P0.05). Conclusion when diabetic retinopathy is associated with iris neovascularization after operation, Lei Zhu McAb can effectively eliminate neovascularization, reduce the incidence of neovascular glaucoma, and reduce the incidence of volume blood in anterior chamber and glass. Improve the visual acuity of patients effectively in a certain time.
【作者单位】： 南昌大学第二附属医院眼科;南昌大学第一附属医院血液内科;
【基金】：国家自然科学基金资助(编号:81460088)~~
【分类号】：R587.2;R779.6
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