血清VEGF-A及其受体VEGFR-2水平与鼻咽癌患者淋巴结转移的关系

发布时间：2018-11-09 08:33

【摘要】：目的：探讨鼻咽癌(NPC)患者血清中VEGF-A/VEGFR-2水平,及其与鼻咽癌患者临床病理参数和和患者淋巴结转移的关系。方法：用酶联免疫吸附法(ELISA)定量检测32例鼻咽癌初治患者、9例鼻咽癌治疗后复发患者、21例鼻咽癌治疗后完全缓解者、6例鼻咽癌远处转移患者血清中VEGF-A和VEGFR-2的浓度,并且与20例健康人血清中VEGF-A和VEGFR-2浓度作对照,比较VEGF-A/VEGFR-2水平与各组患者临床病理特征、TNM分期和淋巴结转移的关系。结果：初治及复发组鼻咽癌患者血清VEGF-A、VEGFR-2水平明显高于健康对照组(P0.01)。复发组鼻咽癌患者血清VEGF-A、VEGFR-2水平明显高于完全缓解组(P0.01)。血清VEGF-A和VEGFR-2水平与鼻咽癌T分期及N分期有关(均为P0.01)。存在淋巴结转移的鼻咽癌患者血清VEGF-A和VEGFR-2水平明显高于无淋巴结转移患者,此两分子与鼻咽癌淋巴转移呈正相关。鼻咽癌治疗后复发组患者血清中VEGF-A和VEGFR-2含量显著高于健康对照组人群(P0.01,P0.01)；完全缓解者组VEGF-A和VEGFR-2含量与健康对照组比较无统计学意义(P0.05)；患者血清中VEGF-A和VEGFR-2含量有相关性(r=0.810,P0.05)；结论：鼻咽癌的发生与进展与鼻咽癌患者血清VEGF-A和VEGFR-2含量有关,鼻咽癌患者血清VEGF-A和VEGFR-2含量与患者临床病理TNM分期及淋巴转移相关,可在一定程度上作为判断患者病情进展的指标。VEGF-A/VEGFR-2水平可以作为预测患者是否已发生淋巴转移的指标。
[Abstract]:Objective: to investigate the level of serum VEGF-A/VEGFR-2 in patients with nasopharyngeal carcinoma (NPC) and its relationship with clinicopathological parameters and lymph node metastasis. Methods: enzyme linked immunosorbent assay (ELISA) was used to detect 32 patients with nasopharyngeal carcinoma (NPC), 9 patients with recurrent nasopharyngeal carcinoma (NPC) and 21 patients with complete remission after nasopharyngeal carcinoma (NPC) treatment. The levels of VEGF-A and VEGFR-2 in the serum of 6 patients with distant metastasis of nasopharyngeal carcinoma were compared with those of 20 healthy controls. The levels of VEGF-A/VEGFR-2 were compared with the clinicopathological features of each group. Relationship between TNM staging and lymph node metastasis. Results: the serum VEGF-A,VEGFR-2 levels in nasopharyngeal carcinoma patients were significantly higher than those in healthy controls (P0.01). The serum VEGF-A,VEGFR-2 level in recurrent nasopharyngeal carcinoma patients was significantly higher than that in complete remission group (P0.01). Serum VEGF-A and VEGFR-2 levels were correlated with T stage and N stage of nasopharyngeal carcinoma (P0.01). The serum levels of VEGF-A and VEGFR-2 in patients with lymph node metastasis were significantly higher than those in patients without lymph node metastasis, and the two molecules were positively correlated with lymphatic metastasis of nasopharyngeal carcinoma. The serum levels of VEGF-A and VEGFR-2 in patients with recurrent nasopharyngeal carcinoma were significantly higher than those in healthy controls (P0.01, P0.01). The levels of VEGF-A and VEGFR-2 in the complete remission group were not significantly different from those in the healthy control group (P0.05), and the levels of VEGF-A and VEGFR-2 in the serum of the patients were correlated with those of the healthy control group (P 0.05). Conclusion: the occurrence and progression of nasopharyngeal carcinoma are related to the levels of serum VEGF-A and VEGFR-2 in patients with nasopharyngeal carcinoma. The contents of VEGF-A and VEGFR-2 in serum of patients with nasopharyngeal carcinoma are related to the clinicopathological TNM stage and lymphatic metastasis. VEGF-A/VEGFR-2 level can be used as a predictor of lymphatic metastasis.
【学位授予单位】：桂林医学院
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R739.63

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