雷珠单抗玻璃体内注射对增生型糖尿病视网膜病变玻璃体切割术效果的影响

发布时间：2018-11-17 07:58

【摘要】：目的探讨术前玻璃体内注射雷珠单抗对增生型糖尿病视网膜病变(proliferative diabetic retinopathy,PDR)患者行经平坦部玻璃体切割术(pars plana vitrectomy,PPV)效果的影响。方法回顾性分析157例行PPV的PDR患者,分为PPV术前7d行玻璃体内雷珠单抗注射组(A组)及未注射组(B组)。观察并比较两组PPV术中医源性裂孔的发生、填充物应用和术后玻璃体再出血、高眼压及最佳矫正视力情况。结果 A组患者术中医源性裂孔发生占5.61%,术中填充物应用者占38.21%,术后玻璃体再出血者占15.73%,术后高眼压者占43.82%,治疗稳定后最佳矫正视力0.3者占53.93%;B组患者术中医源性裂孔发生占14.86%,术中填充物应用者占55.41%,术后玻璃体再出血者占33.78%,术后高眼压者占59.45%,治疗稳定后最佳矫正视力0.3者占21.62%,两组各项指标比较差异均有统计学意义(P=0.04、0.02、0.00、0.04、0.00)。结论 PDR患者PPV术前行玻璃体内雷珠单抗注射能减少术中医源性裂孔的发生及玻璃体腔填充物的应用,降低术后玻璃体腔再出血及高眼压发生的几率,并可使患者获得较好的术后视力。
[Abstract]:Objective to investigate the effect of intravitreous injection of leizumab on (pars plana vitrectomy,PPV in patients with proliferative diabetic retinopathy (proliferative diabetic retinopathy,PDR). Methods 157 PDR patients with PPV were divided into two groups: group A (group A) and group B (group B) treated with vitreous intravitreous injection 7 days before PPV. To observe and compare the occurrence of iatrogenic holes, the application of fillers and vitreous rebleeding, high intraocular pressure and best corrected visual acuity in PPV. Results in group A, iatrogenic hiatus occurred in 5.61 cases, intraoperative filling was used in 38.21 cases, vitreous rebleeding occurred in 15.73 cases, postoperative intraocular pressure was 43.82%. The best corrected visual acuity (BCVA) after treatment was 0.3% (53.93%). In group B, iatrogenic hiatus occurred in 14.86 cases, intraoperative filling accounted for 55.41%, vitreous rebleeding accounted for 33.78%, postoperative intraocular hypertension accounted for 59.45%. The best corrected visual acuity (BCVA) was 0.3 (21.62%) after treatment, and the differences between the two groups were statistically significant (P < 0.05). Conclusion injection of intravitreous intravitreal antigens to PDR patients with PPV before operation can reduce the incidence of iatrogenic holes and the application of intravitreal fillers, and reduce the incidence of postoperative intravitreal rebleeding and high intraocular pressure. And can make the patient obtain better postoperative visual acuity.
【作者单位】：潍坊医学院附属医院眼科;
【分类号】：R779.6

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