25-羟基维生素D与干眼的相关性研究

发布时间：2018-11-17 07:39

【摘要】：目的探讨血清25-羟基维生素D[25(OH)D]和干眼(dry eye,DE)发生的关系。方法本研究共纳入58例DE患者(DE组,n=58)及30例健康对照者(对照组,n=30),采用酶联免疫吸附法(ELISA)检测血清25(OH)D含量,分析血清25(OH)D与眼表疾病指数(ocular surface disease index,OSDI)量表、泪膜破裂时间(break-up time,BUT)及泪液分泌试验(Schirmer I test,SIT)的相关性。结果 DE组SIT为(7.47±3.01)mm/5 min,较对照组(14.56±3.48)mm/5min明显下降(t=9.926,P=0.000),DE组BUT为(6.03±2.14)s,明显低于对照组(12.05±3.27)s(t=10.392,P=0.000),而DE组OSDI评分(36.19±17.23)分显著高于对照组(16.67±5.01)分(t=6.059,P=0.000)。DE组血清25(OH)D水平(18.42±7.57)ng·mL~(-1)明显低于对照组(32.49±12.85)ng·mL~(-1)(t=6.467,P=0.000)。血清25(OH)D缺乏在DE组中更常见(χ~2=30.995,P=0.000)。Pearson相关分析显示,血清25(OH)D水平与SIT呈正相关(r=0.652,P=0.000),与BUT(r=-0.531,P=0.000)、OSDI(r=-0.480,P=0.000)均呈负相关。结论低血清25(OH)D水平可能与DE发生显著相关。
[Abstract]:Objective to investigate the relationship between serum 25-hydroxyvitamin D [25 (OH) D] and dry eye (dry eye,DE). Methods A total of 58 patients with DE (DE group, nun58) and 30 healthy controls (control group, nun30) were enrolled in this study. The serum 25 (OH) D levels were detected by Elisa (ELISA). The correlation between serum 25 (OH) D and ocular surface disease index (ocular surface disease index,OSDI), tear film rupture time (break-up time,BUT) and tear secretion test (Schirmer I test,SIT) was analyzed. Results the SIT of DE group was (7.47 卤3.01) mm/5 min, significantly lower than that of control group (14.56 卤3.48) mm/5min (t = 9.926 ~ 0.000 BUT = (6.03 卤2.14) s). The OSDI score of DE group (36.19 卤17.23) was significantly higher than that of control group (16.67 卤5.01) (t = 6.059). The serum level of 25 (OH) D (18.42 卤7.57) ng mL~ (-1) in 0.000). DE group was significantly lower than that in the control group (32.49 卤12.85 ng mL~ (-1). Serum 25 (OH) D deficiency was more common in DE group (蠂 ~ 2 = 30.995P ~ + 0.000). Pearson correlation analysis showed that the serum 25 (OH) D level was positively correlated with SIT (r = 0.652) and BUT (r = -0.531P ~ (0.000). OSDI (r-0.480) was negatively correlated. Conclusion low serum 25 (OH) D level may be significantly correlated with DE.
【作者单位】：首都医科大学密云教学医院眼科;
【分类号】：R777.34

【相似文献】