双水平气道正压通气治疗对老年阻塞性睡眠呼吸暂停低通气综合征患者认知功能及血清5-羟色胺的影响

发布时间：2018-11-19 16:32

【摘要】：目的观察双水平气道正压通气(Bi PAP)治疗老年阻塞性睡眠呼吸暂停低通气综合征(OSAHS)前后患者认知功能及血清5-羟色胺(5-HT)水平的影响。方法根据睡眠呼吸暂停低通气指数(AHI)与血氧饱和度将老年OSAHS患者分为两组(中度组,重度组),给予两组患者BiPAP治疗,通过蒙特利尔认知评估量表(Mo CA)观察治疗前后OSAHS患者认知功能,采用酶联免疫吸附法(ELISA)测定治疗前后血清5-HT的水平。结果治疗前与中度OSAHS患者比较,重度OSAHS患者认知功能损害较重,5-HT水平较高;经Bi PAP治疗后,与治疗前比较,中、重度OSAHS患者的认知功能均有改善,5-HT水平均有下降。中、重度OSAHS患者均认知功能损害,且与5-HT水平呈负相关。结论经Bi PAP治疗后中重度患者认知功能明显改善,可能与Bi PAP改善了上气道阻塞,下调了5-HT水平有关。
[Abstract]:Objective to observe the effects of bi-level positive airway pressure (Bi PAP) on cognitive function and serotonin (5-HT) level in elderly patients with obstructive sleep apnea hypopnea syndrome (OSAS) before and after (OSAHS). Methods elderly patients with OSAHS were divided into two groups according to sleep apnea hypopnea index (AHI) and oxygen saturation. The patients were treated with BiPAP. The cognitive function of patients with OSAHS before and after treatment was observed by Montreal Cognitive Assessment scale (Mo CA). The serum 5-HT levels were measured by (ELISA) before and after treatment with enzyme-linked immunosorbent assay (Elisa). Results compared with moderate OSAHS patients, the patients with severe OSAHS had more severe cognitive impairment and higher 5-HT level before treatment. After Bi PAP treatment, the cognitive function and 5-HT level of moderate and severe OSAHS patients were improved and decreased. Cognitive impairment in moderate and severe OSAHS patients was negatively correlated with 5-HT level. Conclusion the cognitive function of moderate and severe patients improved significantly after Bi PAP treatment, which may be related to the improvement of upper airway obstruction by Bi PAP and the down-regulation of 5-HT level.
【作者单位】：河北联合大学附属医院呼吸内科;
【分类号】：R563

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