鼻咽癌残留的保守治疗与鼻内镜下手术治疗的效果与安全性分析

发布时间：2018-12-07 11:50

【摘要】：目的:对比鼻咽癌残留的保守治疗与鼻内镜下手术治疗的效果与安全性。方法:鼻咽癌残留患者82例,根据入院顺序分为鼻内镜组与挽救性放疗组各41例。挽救性放疗组给予放疗保守治疗,鼻内镜组给予鼻内镜下手术治疗,观察两组的预后疗效与并发症发生情况。结果:治疗6个月后鼻内镜组与挽救性放疗组的有效率分别为92.7%和75.6%,鼻内镜组的有效率高于挽救性放疗组(P0.05)。两组均未出现鼻咽部大出血及邻近重要器官损伤等严重并发症,其他并发症经对症处理后好转。鼻内镜组的总生存时间、局部无复发生存时间及远处无转移生存时间分别为(34.24±2.19)个月、(28.45±1.98)个月和(26.33±2.88)个月,均明显高于挽救性放疗组的(26.46±1.98)个月、(21.87±2.09)个月和(20.44±3.19)个月(P0.05)。结论:相对于保守放疗,鼻内镜下手术治疗鼻咽癌残留能提高疗效,安全性良好,延长了患者的生存时间,有很好的应用价值。
[Abstract]:Objective: to compare the efficacy and safety of conservative treatment and endoscopic surgery for nasopharyngeal carcinoma. Methods: 82 patients with residual nasopharyngeal carcinoma were divided into nasal endoscopic group and salvage radiotherapy group according to admission order. The patients in the salvage radiotherapy group were treated with conservative radiotherapy, while the patients in the endoscopic group were treated with endoscopic surgery. The prognosis and complications of the two groups were observed. Results: after 6 months of treatment, the effective rates of endoscopic group and salvage radiotherapy group were 92.7% and 75.6%, respectively. The effective rate of nasal endoscopy group was higher than that of salvage radiotherapy group (P0.05). There were no serious complications such as nasopharyngeal hemorrhage and adjacent important organ injury in both groups, and other complications were improved after symptomatic treatment. The total survival time, local non-recurrence survival time and distant non-metastasis survival time of endoscopic group were (34.24 卤2.19) months, (28.45 卤1.98) months and (26.33 卤2.88) months, respectively. They were significantly higher than those in the rescue radiotherapy group (26.46 卤1.98 months, 21.87 卤2.09 months and 20.44 卤3.19 months, P0.05). Conclusion: compared with conservative radiotherapy, endoscopic surgery for residual nasopharyngeal carcinoma can improve the efficacy, safety and prolong the survival time of patients.
【作者单位】：湖北医药学院附属东风医院耳鼻咽喉科;
【分类号】：R739.63

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