EOS和趋化因子Eotaxin在阿司匹林三联征发病机制中的相关研究

发布时间：2018-12-13 21:41

【摘要】：目的：检测EOS分布情况和Eotaxin在鼻息肉组织中的表达，探讨其在阿司匹林三联征发病过程中的作用及意义。方法：取94例鼻内镜手术患者鼻息肉组织（其中实验组1ST患者34例，实验组2CRSwNP合并哮喘患者30例，对照组CRSwNP患者30例），应用免疫组化SP法及HE染色检测Eotaxin的表达和EOS的分布，以SPSS17.0软件对数据进行统计学分析。结果：EOS在三组患者鼻息肉组织中均大量浸润，分布部位不同，EOS总计数均数分别为80.02±6.11、76.62±5.22、65.97±4.78，，三组比较差异有统计学意义（P1、P2＜0.05，P3＞0.05）；Eotaxin在实验组1、2及对照组均有阳性表达，三组阳性表达计数呈递减性，两两比较且其差异均有统计学意义(1）P2）3）、P、P＜0.05)。结论：EOS的高度聚集浸润是阿司匹林三联征重要的病理表现，Eotaxin的高表达在阿司匹林三联征患者的呼吸道炎症反应中发挥重要的作用；Eotaxin为阿司匹林三联征患者鼻息肉多发和易复发提供了炎症基础。
[Abstract]:Objective: to detect the distribution of EOS and the expression of Eotaxin in nasal polyps, and to explore the role and significance of Eotaxin in the pathogenesis of aspirin triple syndrome. Methods: the expression of Eotaxin and the distribution of EOS were detected by immunohistochemical SP method and HE staining in 94 cases of nasal polyps (34 cases of experimental group with 1ST, 30 cases of experimental group with 2CRSwNP combined with asthma and 30 cases of control group). The data were analyzed by SPSS17.0 software. Results: EOS was infiltrated in nasal polyps in all three groups, and the distribution of EOS was different. The mean of EOS was 80.02 卤6.1176.62 卤5.2265.97 卤4.78, respectively. The difference among the three groups was statistically significant (P1P _ 2 < 0.05), and there was no significant difference between the three groups (P _ (1) P _ (2) < 0.05). P3 > 0.05); The positive expression of Eotaxin was found in both experimental group (1) and control group (P < 0. 05). The number of positive expression in the three groups was decreased, and the difference was statistically significant (1) P2) 3 (P < 0. 05). Conclusion: the high aggregation and infiltration of EOS is an important pathological manifestation of aspirin triple sign. The high expression of Eotaxin plays an important role in the respiratory tract inflammation in patients with aspirin triple syndrome. Eotaxin provides an inflammatory basis for multiple nasal polyps and easy recurrence in patients with triple aspirin syndrome.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R765.21

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