单唾液酸四己糖神经节苷脂与视神经病变预后的相关性

发布时间：2018-12-17 11:39

【摘要】：目的评估单唾液酸四己糖神经节苷脂(Monosialotetera-hexosylgangliosideGM1)与视神经病变预后的相关性。方法采用回顾性病例对照研究，收集首次发病的视神经病变患者143例196眼的临床资料,将可能影响研究对象视力预后的因素：性别、年龄、疾病类别、治疗前（矫正）视力、治疗前发病时间、是否接受GM1治疗为协变量；疗效、首次视力提高的时间、治疗两周后（矫正）视力为因变量，用多元Logistic回归分析探讨GM1对视神经病变视力预后的影响。结果单因素分析：GM1与视神经病变的疗效、首次视力提高时间、治疗两周后（矫正）视力关联有统计学意义，其P值、OR、95%CI分别为（P=0.000，OR=0.313，95%CI：0.170-0.578；P=0.001，OR=0.391，95%CI：0.219-0.698；p=0.000，，OR=0.350，95%CI:0.196-0.625）。多因素分析：调整其他混杂因素后，GM1与视神经病变的疗效、首次视力提高时间、治疗两周后（矫正）视力显示有明显的促进作用。其调整OR值，95%CI分别为（OR=0.311，95%CI：0.159-0.606；OR=0.424，95%CI：0.224,0.805；OR=0.308，95%CI：0.141-0.671）。结论GM1对视神经疾病的恢复有明显促进作用，有助于获得较好的视力预后。
[Abstract]:Objective to evaluate the correlation between monosialate tetrahexose ganglioside (Monosialotetera-hexosylgangliosideGM1) and prognosis of optic neuropathy. Methods A retrospective case-control study was conducted to collect the clinical data of 196 eyes of 143 patients with first onset optic neuropathy. The factors that might affect the visual outcome of the subjects were sex, age, disease type, visual acuity before treatment. The time of onset before treatment, whether or not to receive GM1 treatment as a co-variable; The effect, the time of the first visual acuity improvement and the visual acuity after two weeks of treatment were regarded as dependent variables. The influence of GM1 on the visual acuity prognosis of optic neuropathy was studied by multivariate Logistic regression analysis. Results univariate analysis showed that there were significant differences between GM1 and the curative effect of optic neuropathy, the time of first visual acuity improvement, and the visual acuity after two weeks of treatment (P = 0.000, P = 0.000). OR=0.313,95%CI:0.170-0.578; P = 0.219-0.698p = 0.0000.350 / 95CI: 0.196-0.625). Multivariate analysis: after adjusting other confounding factors, the effect of GM1 and optic neuropathy, the time of the first visual acuity improvement, and the visual acuity after two weeks of treatment were significantly improved. It adjusts the OR value, 95%CI is (OR=0.311,95%CI:0.159-0.606;OR=0.424,95%CI:0.224,0.805;OR=0.308,95%CI:0.141-0.671). Conclusion GM1 plays an important role in the recovery of optic nerve disease.
【学位授予单位】：华中科技大学
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R774.6

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