高海拔地区耳后注射甲强龙辅助治疗突发性聋的临床研究与分析

发布时间：2018-12-23 09:05

【摘要】：目的研究分析耳后注射甲强龙与否治疗高海拔地区突发性聋的临床疗效,为在高海拔地区应用甲强龙治疗突发性聋的给药途径提供临床依据。方法收集青海省人民医院耳鼻喉科于2015.09~2016.12间住院的突发性聋患者资料,满足筛选条件者共171人,按患者治疗方式分为耳后针治疗组及常规治疗组,两组都应用常规药物治疗,且用药方法一致。耳后针治疗组在疗程的第6、8、10、12、14天给予耳后注射甲强龙40mg/次。疗程均为听力恢复正常或15天。患者均在入院治疗前、治疗过程中及治疗结束后行纯音测听检查。将两组的治疗有效率、治疗后听力平均阈值及听力提高的平均阈值进行比较。结果耳后针治疗组与常规治疗组治疗高海拔地区突发性聋患者的治疗有效率分别是63.6%、30.9%,差异有统计学意义(P0.05)。耳后针治疗组患者治疗前平均听阈值为54.89±21.47d B,治疗后平均听阈值为30.89±16.90d B,治疗前后平均听阈值差异有统计学意义(P0.001);常规治疗组患者治疗前平均听阈值为50.98±19.02d B,治疗后平均听阈值为42.23±20.29d B,治疗前后平均听阈值差异有统计学意义(P0.001);两组患者治疗后平均听阈值差异有统计学意义(P0.001);耳后针治疗组与常规治疗组患者治疗后听力提高平均听阈值分别为24.00±11.76d B、8.75±15.18d B,两组患者治疗后听力提高平均听阈值差异有统计学意义(P0.001);两组平坦下降型治疗有效率分别为59.1%、26.2%,差异有统计学意义(P0.05)。结论在常规治疗高海拔地区突发性聋的方法上加用耳后注射甲强龙起到了辅助治疗的作用,提高了疗效。
[Abstract]:Objective to study the clinical effect of injection of mepraxone in the treatment of sudden deafness at high altitude, and to provide the clinical basis for the treatment of sudden deafness with methylenolone at high altitude. Methods data of 171 patients with sudden deafness who were hospitalized in the Department of Otorhinolaryngology, Qinghai Provincial people's Hospital from May 09 to June 2016 were collected. 171 patients were selected and divided into two groups according to the treatment methods: the group treated with retroauricular acupuncture and the group treated with routine treatment. Both groups were treated with routine drugs, and the methods were the same. The retroauricular acupuncture group was given retroauricular injection of methylenolone 40mg/ at the 6th day of treatment. The course of treatment was normal hearing recovery or 15 days. All patients underwent pure tone audiometry before admission, during treatment and after treatment. The effective rate, the average hearing threshold after treatment and the average threshold of hearing improvement were compared between the two groups. Results the effective rate of treatment of sudden deafness in high altitude area was 63.60.The effective rate was 63.60.The difference was statistically significant (P0.05). The mean hearing threshold before and after treatment was 54.89 卤21.47 dB and 30.89 卤16.90 dB respectively in the retroauricular acupuncture group. There was significant difference in the mean hearing threshold before and after treatment (P0.001). The average hearing threshold before and after treatment was 50.98 卤19.02 dB and 42.23 卤20.29 dB respectively in the routine treatment group. There was significant difference in the mean hearing threshold before and after treatment (P0.001). There was significant difference in the average auditory threshold between the two groups after treatment (P0.001). The average hearing threshold of the patients in the retroauricular acupuncture group and the routine treatment group was 24.00 卤11.76 days (8.75 卤15.18 dB), respectively. There was significant difference in the average hearing threshold between the two groups (P0.001). The effective rate of flat descent therapy in the two groups was 59.1 and 26.2respectively, the difference was statistically significant (P0.05). Conclusion the conventional treatment of sudden deafness at high altitude with retroauricular injection of methylenolone plays a role in adjuvant treatment and improves the curative effect.
【学位授予单位】：青海大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R764.437

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