慢性化脓性中耳炎分泌物的细菌培养及药敏试验

发布时间：2019-01-07 07:20

【摘要】：目的探讨慢性化脓性中耳炎患者分泌物的细菌培养与药敏试验结果情况。方法收集2013年10月-2015年10月收治的慢性化脓性中耳炎住院患者80例,取患者的耳道分泌物行常规细菌分离培养及细菌鉴定与药敏试验分析。结果 80例患者的分泌物标本中共68例患者培养出病原菌,病原菌检出率为85.00%,共培养出74株病原菌,其中革兰阳性菌32株占43.24%,革兰阴性菌32株占43.24%,真菌10株占13.51%,金黄色葡萄球菌与表皮葡萄球菌对青霉素的耐药率80%,对克林霉素与红霉素的耐药率50%;铜绿假单胞菌与肺炎克雷伯菌对氨苄西林、头孢唑林、头孢曲松、头孢替坦、呋喃妥因、氨苄西林舒巴坦、磺胺甲VA唑/甲氧苄啶的耐药率90%,对头孢噻肟的耐药率60%;革兰阳性菌与革兰阴性菌对左氧氟沙星等常用药物的敏感性均较高;白假丝酵母菌与曲霉菌对酮康唑、益康唑、咪康唑有一定耐药性,对制霉菌素、两性霉素、5-氟胞嘧啶敏感性高。结论慢性化脓性中耳炎患者分泌物的常见病原菌为金黄色葡萄球菌、表皮葡萄球菌及铜绿假单胞菌,临床需根据细菌培养及药敏试验结果选取合理的抗菌药物。
[Abstract]:Objective to investigate the results of bacterial culture and drug sensitivity test in patients with chronic suppurative otitis media. Methods from October 2013 to October 2015, 80 patients with chronic suppurative otitis media were collected and their ear canal secretions were collected for routine bacterial isolation, bacterial identification and drug sensitivity test. Results A total of 68 cases of pathogenic bacteria were cultured in the secretion samples of 80 patients. The detection rate of pathogenic bacteria was 85.00. A total of 74 strains of pathogenic bacteria were cultured, of which 32 strains were Gram-positive bacteria, 32 strains were Gram-negative bacteria, and 32 strains were Gram-negative bacteria. The resistance rate of Staphylococcus aureus and Staphylococcus epidermidis to penicillin was 80 and 50 to clindamycin and erythromycin respectively. The resistance rates of Pseudomonas aeruginosa and Klebsiella pneumoniae to ampicillin, cefazolin, ceftriaxone, ceftitan, furantoin, ampicillin, sulbactam, sulfamethoxazole / trimethoprim were 90 and 60, respectively. The sensitivity of Gram-positive bacteria and Gram-negative bacteria to levofloxacin and other commonly used drugs were higher. Candida albicans and Aspergillus were resistant to ketoconazole, econazole and miconazole, and had high sensitivity to nystatin, amphotericin and 5-fluorocytosine. Conclusion Staphylococcus aureus, Staphylococcus epidermidis and Pseudomonas aeruginosa are common pathogens in the secretion of patients with chronic suppurative otitis media.
【作者单位】：濮阳市油田总医院耳鼻咽喉科;
【分类号】：R764.21

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