脑安胶囊对睡眠呼吸暂停综合征患者认知功能的影响

发布时间：2019-01-27 21:25

【摘要】：①目的探讨脑安胶囊对睡眠呼吸暂停综合征患者认知功能障碍的影响。②方法选择2013年9月~2015年5月华北理工大学附属医院呼吸科收治的睡眠呼吸暂停综合征伴认知障碍患者60例,按照随机数字表法分为对照组和观察组,各30例。对照组患者给予常规无创呼吸机辅助通气治疗,观察组患者在常规无创呼吸机辅助通气治疗基础上给予脑安胶囊口服,两组患者均治疗6个月。采用蒙特利尔认知评估量表(Montreal cognitive assessment scale,MoCA)比较两组患者治疗前后认知功能的变化,并观察治疗期间脑安胶囊不良反应发生情况。③结果治疗前两组患者认知功能MoCA各项总评分比较,差异无统计学意义(P0.05)。治疗后两组患者认知功能MoCA各项总评分均高于治疗前水平,差异有统计学意义(P0.05);与对照组比较,治疗后观察组认知功能MoCA各项评分明显降低,差异有统计学意义(P0.05)。④结论脑安胶囊可能在一定程度上改善睡眠呼吸暂停综合征患者的认知功能。
[Abstract]:Objective to investigate the effect of Naoan capsule on cognitive dysfunction in patients with sleep apnea syndrome. 2 methods Sleep apnea syndrome patients were selected from September 2013 to May 2015 in Department of Respiratory, affiliated Hospital of Huabei University of Science and Technology. 60 patients with cognitive impairment, According to the random digital table method, 30 cases were divided into control group and observation group. The patients in the control group were treated with routine non-invasive ventilator assisted ventilation, and the patients in the observation group were treated with Naoan capsule on the basis of routine non-invasive ventilator assisted ventilation. The patients in both groups were treated for 6 months. Montreal Cognitive Assessment scale (Montreal cognitive assessment scale,MoCA) was used to compare the changes of cognitive function between the two groups before and after treatment. The adverse reactions of Naoan capsule were observed during the treatment. 3 results there was no significant difference in the total scores of cognitive function MoCA between the two groups before treatment (P0.05). After treatment, the MoCA scores of cognitive function in the two groups were higher than those before treatment, and the difference was statistically significant (P0.05). Compared with the control group, the scores of MoCA in the observation group were significantly decreased after treatment (P0.05). 4 conclusion Naoan capsule may improve the cognitive function of the patients with sleep apnea syndrome to some extent.
【作者单位】：华北理工大学附属医院呼吸科;
【基金】：唐山市科技局课题(编号:13130221b)
【分类号】：R766

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