玻璃体注射雷珠单抗治疗老年性黄斑变性黄斑水肿与视网膜静脉阻塞性黄斑水肿的短期疗效观察

发布时间：2019-02-12 15:36

【摘要】：目的观察玻璃体注射雷珠单抗治疗老年黄斑变性黄斑水肿(AMD-ME)与视网膜静脉阻塞性黄斑水肿(RVO-ME)的短期临床效果。设计回顾性病例系列。研究对象2015年10月至2016年7月确诊为AMD-ME及RVO-ME的患者共30例(30眼),各15例(15眼)。方法患眼接受玻璃体注射雷珠单抗(0.5 mg/0.05 ml)治疗,采用1+PRN的注射方法,比较治疗前和治疗后1天、1个月最佳矫正视力(BCVA)、眼压(IOP)、黄斑中心凹视网膜厚度(CMT)、注射后消除的水肿高度,评价每次随访时检查结果。主要指标BCVA、CMT、消除的水肿高度、IOP。结果 AMD-ME组及RVO-ME组注射雷珠单抗后1天、1个月的BCVA均较术前提高(P=0.000、0.000)。AMD-ME组及RVO-ME组每次治疗前和治疗后1个月CMT厚度均降低(P=0.000、0.000)。治疗过程中患者眼压与治疗前比较并无明显变化(P=0.096、0.066、0.213、0.088、0.240、0.337)。结论玻璃体注射雷珠单抗治疗AMD-ME及RVO-ME在短期内均可减轻黄斑水肿和改善视力,两者治疗效果无明显差异。
[Abstract]:Objective to observe the short-term clinical effect of vitreous injection of Leizhu McAb in the treatment of senile macular edema (AMD-ME) and retinal vein obstructive macular edema (RVO-ME). Design retrospective case series. Subjects from October 2015 to July 2016, 30 patients (30 eyes) with AMD-ME and RVO-ME were diagnosed, 15 patients (15 eyes) each. Methods the patients were treated with vitreous injection of Lei Zhu McAb (0.5 mg/0.05 ml). The best corrected visual acuity (BCVA),) intraocular pressure (IOP),) was compared with that of 1 PRN injection before and 1 day after treatment. Macular fovea retinal thickness was removed after (CMT), injection and the results were evaluated at each follow-up. Main outcome measures Edema height eliminated by BCVA,CMT, IOP. Results in AMD-ME group and RVO-ME group, 1 month BCVA was significantly higher than that before operation (P0. 000 卤0. 000), and CMT thickness in AMD-ME group and RVO-ME group was decreased before and 1 month after treatment (P0. 000 ~ 0. 000). There was no significant change in IOP during the course of treatment compared with that before treatment (P < 0.096 ~ 0.06 ~ 0.06 ~ 0.213 ~ 0.088 ~ 0.240 ~ 0.337). Conclusion vitreous injection of Leizhu McAb can reduce macular edema and improve visual acuity in a short period of time after treatment with AMD-ME and RVO-ME, but there is no significant difference between the two.
【作者单位】：哈尔滨医科大学第一附属医院眼科;
【基金】：国家自然科学基金(81470618)
【分类号】：R774.5

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