视网膜静脉阻塞患者血小板参数及同型半胱氨酸水平的临床分析

发布时间：2019-02-13 09:31

【摘要】：目的检测视网膜静脉阻塞(retinal vein occlusion,RVO)患者的同型半胱氨酸(homocysteine,Hcy)水平和血小板参数,包括血小板计数(platelet,PLT)、血小板平均体积(mean platelet volume,MPV),探讨两者是否作为致病因素参与RVO发病。方法对临床诊断为RVO的48例患者(RVO组)进行血PLT、MPV、Hcy测定,包括视网膜分支静脉阻塞(branch retinal vein occlusion,BRVO)患者22例(BRVO组)和视网膜中央静脉阻塞(central retinal vein occlusion,CRVO)患者26例(CRVO组),并与临床诊断为白内障的40例对照组进行比较并作统计学分析。结果 RVO组PLT水平(212.99±50.10)×10~9L~(-1),与对照组PLT水平(198.11±44.69)×10~9L~(-1)比较,差异无统计学意义(P0.05),RVO组MPV与Hcy水平(9.44±0.97)f L、(8.99±0.81)μmol·L~(-1)较对照组(8.66±0.96)f L和(8.38±0.62)μmol·L~(-1)均增高(均为P0.05)。PLT水平在CRVO组(212.27±49.07)×10~9L~(-1)、BRVO组(213.84±52.43)×10~9L~(-1)及对照组间比较差异均无统计学意义(均为P0.05),MPV、Hcy水平在CRVO组(9.48±0.91)f L、(8.97±0.76)μmol·L~(-1)与BRVO组(9.40±1.06)f L、(9.01±0.89)μmol·L~(-1),较对照组均增高(均为P0.05),但在CRVO组与BRVO组间比较差异均无统计学意义(均为P0.05)。结论高MPV、高Hcy可能是引起RVO发病的危险因素,降血小板及降Hcy的治疗从理论上讲是一种积极有效的预防措施。
[Abstract]:Objective to detect the levels of homocysteine (homocysteine,Hcy) and platelet parameters, including platelet count (platelet,PLT) and mean platelet volume (mean platelet volume,MPV) in patients with retinal vein occlusion (retinal vein occlusion,RVO). To explore whether the two factors play a role in the pathogenesis of RVO. Methods Blood PLT,MPV,Hcy was measured in 48 patients with RVO (RVO group), including 22 patients with retinal branch vein occlusion (branch retinal vein occlusion,BRVO) and (central retinal vein occlusion, with central retinal vein occlusion (BRVO group). 26 cases of CRVO (CRVO group) were compared with 40 cases of control group. Results the level of PLT in RVO group was (212.99 卤50.10) 脳 10 ~ (-9) L ~ (-1), and the level of PLT was (198.11 卤44.69) 脳 10 ~ (9) L ~ (-1) in RVO group. There was no significant difference (P0.05) between MPV and Hcy in), RVO group (9.44 卤0.97) f L,). The level of (8.99 卤0.81) 渭 mol L ~ (-1) in CRVO group was significantly higher than that in control group (8.66 卤0.96) f L and (8.38 卤0.62) 渭 mol L ~ (-1) (P0.05). PLT) in CRVO group (212.27 卤49.07) 脳 10 ~ (9) L ~ (-1). There was no significant difference between BRVO group (213.84 卤52.43) 脳 10 ~ (9) L ~ (-1) and control group (P0.05), and MPV,Hcy level was (9.48 卤0.91) f L, in CRVO group. (8.97 卤0.76) 渭 mol L ~ (-1) and BRVO (9.40 卤1.06) f L, (9.01 卤0.89) 渭 mol L ~ (-1), which were higher than those in the control group (P0.05). But there was no significant difference between CRVO group and BRVO group (P0.05). Conclusion High MPV, and high Hcy may be the risk factors of RVO. The treatment of decreasing platelet and decreasing Hcy is an active and effective preventive measure in theory.
【作者单位】：锦州医科大学;锦州医科大学附属第一医院眼科;
【分类号】：R774.1

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