频域OCT检测视野前青光眼黄斑区视网膜神经节细胞复合体厚度的初步研究
发布时间：2019-03-27 19:39
【摘要】：目的探讨黄斑区视网膜神经节细胞复合体(GCC)厚度检测对于诊断视野前青光眼(PPG)患者的意义。设计自身对照研究和病例对照研究。研究对象POAG患者20例40眼(无视野缺损眼为PPG组20眼,视野缺损眼为POAG组20眼)和正常对照者30例30眼。方法采用RTvue SD-OCT进行黄斑区GCC厚度和视盘周围视网膜神经纤维层(RNFL)厚度检测,应用受试者工作特征曲线下面积(AUC)评价各参数区分PPG与正常眼的能力。主要指标GCC与RNFL的厚度以及二者AUC值。结果 PPG组平均GCC厚度(Avg GCC)、上方GCC厚度(Sup GCC)、下方GCC厚度(Inf GCC)、平均RNFL厚度(Avg RNFL)、上方RNFL厚度(Sup RNFL)、下方RNFL厚度(Inf RNFL)与正常对照组相比均变薄,差异有统计学意义(t=5.508,5.402,5.576,6.517,5.849,5.392,P均0.001),但均厚于POAG组,差异有统计学意义(t=4.778,3.698,4.593,5.209,3.757,5.450,P均≤0.002)。PPG组GCC整体丢失体积(GCC-GLV)和局部丢失体积(GCC-FLV)均较正常对照组增大,差异有统计学意义(t=6.539,2.515,P0.001,P=0.021),但较POAG组小,差异有统计学意义(t=6.013,7.669,P均0.001)。Avg GCC、Sup GCC、Inf GCC、GCC-GLV、GCC-FLV、Avg RNFL、Sup RNFL和Inf RNFL厚度诊断PPG的AUC值分别为0.910、0.898、0.908、0.983、0.724、0.930、0.918、0.863,其中GCC参数中诊断效能最高的GCC-GLV与RNFL参数中的Avg RNFL的AUC值采用z检验无统计学差异(P0.05)。结论 GCC厚度可作为筛选PPG的有效指标。
[Abstract]:Objective to investigate the significance of detecting the thickness of retinal ganglion cell complex (GCC) in macular area in the diagnosis of pre-visual glaucoma (PPG). Self-control and case-control studies were designed. 20 patients with POAG (20 eyes without visual field defect, 20 eyes with POAG group) and 30 cases (30 eyes) with normal control were enrolled in the study. The patients were divided into two groups: PPG group (20 eyes) and POAG group (20 eyes). Methods the thickness of GCC in macular area and the thickness of (RNFL) in retinal nerve fiber layer around optic disc were measured by RTvue SD-OCT. The ability of distinguishing PPG from normal eyes was evaluated by area (AUC) under the receiver's operating characteristic curve. Main measures: thickness of GCC and RNFL and their AUC values. Results the average thickness of GCC in PPG group was higher than that in control group (Avg GCC), GCC, (Sup GCC), (Inf GCC), RNFL, (Avg RNFL), RNFL, (Sup RNFL), RNFL, (Inf RNFL), and the thickness of (Inf RNFL) was thinner than that in control group. The difference was statistically significant (t = 5.508,5.402, 5.576,6.517,5.849,5.392, P 0.001), but thicker than that of POAG (t = 4.778, 3.698,4.593,5.209, 3.757, 5.450, respectively). The total loss volume (GCC-GLV) and local loss volume (GCC-FLV) of GCC in both P 鈮，
本文编号：2448497
[Abstract]:Objective to investigate the significance of detecting the thickness of retinal ganglion cell complex (GCC) in macular area in the diagnosis of pre-visual glaucoma (PPG). Self-control and case-control studies were designed. 20 patients with POAG (20 eyes without visual field defect, 20 eyes with POAG group) and 30 cases (30 eyes) with normal control were enrolled in the study. The patients were divided into two groups: PPG group (20 eyes) and POAG group (20 eyes). Methods the thickness of GCC in macular area and the thickness of (RNFL) in retinal nerve fiber layer around optic disc were measured by RTvue SD-OCT. The ability of distinguishing PPG from normal eyes was evaluated by area (AUC) under the receiver's operating characteristic curve. Main measures: thickness of GCC and RNFL and their AUC values. Results the average thickness of GCC in PPG group was higher than that in control group (Avg GCC), GCC, (Sup GCC), (Inf GCC), RNFL, (Avg RNFL), RNFL, (Sup RNFL), RNFL, (Inf RNFL), and the thickness of (Inf RNFL) was thinner than that in control group. The difference was statistically significant (t = 5.508,5.402, 5.576,6.517,5.849,5.392, P 0.001), but thicker than that of POAG (t = 4.778, 3.698,4.593,5.209, 3.757, 5.450, respectively). The total loss volume (GCC-GLV) and local loss volume (GCC-FLV) of GCC in both P 鈮，
本文编号：2448497
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