神经生长因子凝胶保护青光眼视神经的临床效果

发布时间：2019-03-31 07:36

【摘要】：目的探讨神经生长因子(NGF)凝胶对原发性闭角型青光眼患者术后视神经的保护作用。方法选取60例86眼原发性青光眼患者为研究对象,随机分为观察组(小梁切除术后采用NGF凝胶做后续治疗)28例42眼和对照组(术后采用三磷酸腺苷二钠片作后续治疗)32例44眼,所有患者在结束手术后坚持用药4 w,比较两组患者术后用药前和术后2、6个月的视力、眼压、视野、视网膜神经纤维层厚度(RNFL)和视乳头杯盘比。结果观察组患者术后用药前视力为0.41±0.17,术后2个月为0.50±0.20,术后6个月为0.49±0.25,对照组患者术后用药前视力为0.42±0.22,术后2个月为0.42±0.19,术后6个月为0.41±0.28,观察组术后2、6个月的视力均高于同期的对照组(P均0.05)。两组患者眼压在术后用药前、术后2、6个月均没有统计学差异。观察组视野平均视敏度在术后2、6个月均明显高于对照组,视野平均缺损值在术后6个月低于对照组(P0.05)。观察组患者在术后6个月时,RNFL明显大于对照组,杯盘比明显小于对照组(P0.05);但在术后2个月两组患者无统计学差异。结论NGF凝胶用于原发性青光眼患者术后治疗有显著的临床效果,对视神经有很好的保护作用。
[Abstract]:Objective to investigate the protective effect of nerve growth factor (NGF) gel on the optic nerve of patients with primary angle closure glaucoma after operation. Methods 60 patients (86 eyes) with primary glaucoma were selected as subjects. They were randomly divided into observation group (follow-up treatment with NGF gel after trabeculectomy) and control group (follow-up treatment with adenosine triphosphate disodium tablets). The visual acuity, intraocular pressure (IOP), visual field, retinal nerve fiber layer thickness (RNFL) and papillary cup-disk ratio were compared between the two groups before and 2 and 6 months after operation. Results the visual acuity of the patients in the observation group was 0.41 卤0.17, 0.50 卤0.20 at 2 months, 0.49 卤0.25 at 6 months after operation, 0.42 卤0.22 before and 0.42 卤0.19 at 2 months after operation, and 0.42 卤0.22 in the control group. 6 months after operation, the visual acuity of the observation group was 0.41 卤0.28, and the visual acuity of the observation group was higher than that of the control group at 2 and 6 months after operation (P 0.05). There was no significant difference in IOP between the two groups before and 2 and 6 months after operation. The visual field average visual acuity in the observation group was significantly higher than that in the control group at 2 months and 6 months after operation, and the mean visual field defect value was lower than that in the control group at 6 months after operation (P0.05). At 6 months after operation, the RNFL of the observation group was significantly higher than that of the control group, and the ratio of cup to plate was significantly lower than that of the control group (P0.05), but there was no statistical difference between the two groups at 2 months after operation. Conclusion NGF gel has significant clinical effect and good protective effect on optic nerve in patients with primary glaucoma after operation.
【作者单位】：华中科技大学同济医学院附属武汉中心医院眼科;
【基金】：国家自然科学基金资助(81300761)
【分类号】：R779.6

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