幽门螺杆菌感染与保定地区原发性青光眼的相关性

发布时间：2019-04-19 13:57

【摘要】：目的探讨幽门螺杆菌(Hp)感染与原发性闭型青光眼(PACG)及原发性开角型青光眼(POAG)的相关性。方法选取保定地区2013年5月至2016年5月83例POAG患者、82例PACG患者及50例健康志愿者,所有受试者均接受14C-尿素呼气试验进行Hp检测,同时所有患者均进行光学相干断层成像(OCT)检查视网膜神经纤维层(RNFL)厚度。结果 POAG组、PACG组、健康对照组14C-尿素呼气试验Hp阳性率分别为73.5%、52.4%、34.0%,组间两两比较均有统计学差异(P0.05);大、中、小视盘RNFL全周厚度在三组间差异具有统计学意义(P0.05),与健康对照组比较,POAG组与PACG组的大、中、小视盘RNFL全周厚度均明显减小(P0.05),且POAG组明显低于PACG组(P0.05);直线相关分析发现,POAG组Hp浓度与RNFL厚度呈负相关(r=-0.488,P0.05);PACG组也呈现负相关关系,但是无统计学意义(r=-0.013,P0.05)。结论保定地区POAG与Hp感染可能密切相关,可能Hp感染为POAG的重要危险因素。
[Abstract]:Objective to investigate the relationship between Helicobacter pylori (HP) (Hp) infection and primary closure glaucoma (PACG) and primary open angle glaucoma (POAG). Methods from May 2013 to May 2016, 83 patients with POAG, 82 patients with PACG and 50 healthy volunteers were selected. All subjects were tested for Hp by 14C-urea breath test. At the same time, optical coherence tomography (OCT) was performed in all patients to examine the thickness of retinal nerve fiber layer (RNFL). Results the positive rates of 14C-urea breath test Hp in POAG group, PACG group and healthy control group were 73.5%, 52.4% and 34.0%, respectively. There was significant difference between the two groups (P0.05). The whole week thickness of small disc RNFL was significantly different among the three groups (P0.05). Compared with the healthy control group, the whole week thickness of POAG group and PACG group was significantly decreased (P0.05), and the whole week thickness of small optic disc RNFL was significantly decreased (P0.05), while the whole week thickness of small disc RNFL was significantly lower than that of the healthy control group (P0.05). And POAG group was significantly lower than PACG group (P0.05). Linear correlation analysis showed that there was a negative correlation between Hp concentration and RNFL thickness in POAG group (r = 0.488, P 0.05,); PACG group also showed a negative correlation, but there was no statistical significance (r = 0.013, P 0.05). Conclusion POAG may be closely related to Hp infection in Baoding area, and Hp infection may be an important risk factor for POAG.
【作者单位】：保定市第二中心医院眼科;
【分类号】：R775.2

【相似文献】